Ibotenic acid: on the mechanism of its conversion to [3H] muscimol
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Radioanalytical and Nuclear Chemistry"
DOI: 10.1007/s10967-018-6203-8
Abstract: Muscimol is a small but structurally unique isoxazole alkaloid isolated from the mushroom Amanita muscaria. Because of its potent gamma aminobutyric acid (GABA) agonist activity, muscimol was the elusive target of tritiation attempts for many… read more here.
Keywords: conversion muscimol; mechanism conversion; acid mechanism; ibotenic acid ... See more keywords
Ibotenic acid induced lesions impair the modulation of dendritic spine plasticity in the prefrontal cortex and amygdala, a phenomenon that underlies working memory and social behavior.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.173883
Abstract: The lesions induced by Ibotenic acid (IA) emulate some of the symptoms associated with schizophrenia, such as impaired working memory that is predominantly organized by the medial prefrontal cortex (mPFC), or difficulties in social interactions… read more here.
Keywords: working memory; social behavior; ibotenic acid; memory ... See more keywords