Inhibition of Cytochrome P450 2J2-Mediated Metabolism of Rivaroxaban and Arachidonic Acid by Ibrutinib and Osimertinib
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DOI: 10.1124/dmd.122.000928
Abstract: Covalent tyrosine kinase inhibitors (TKIs) ibrutinib and osimertinib are associated with cardiac arrhythmia. The interactions between these TKIs with CYP2J2 that is highly expressed in the human heart are unknown. In vitro metabolism experiments were… read more here.
Keywords: metabolism; mediated metabolism; inhibition; ibrutinib osimertinib ... See more keywords