Artemisinin‐isatin hybrids tethered via ethylene linker and their anti‐lung cancer activity
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200563
Abstract: The synthesized 11 artemisinin‐isatin hybrids 5a–c and 6a–h tethered via ethylene linker were assessed for their in vitro antiproliferative activity against A549 and H1299 nonsmall‐cell lung cancer cell lines as well as their cytotoxicity towards… read more here.
Keywords: lung cancer; artemisinin isatin; ic50; lung ... See more keywords
2‐Phenylquinazolin‐4(3H)‐one scaffold as newly designed, synthesized VEGFR‐2 allosteric inhibitors with potent cytotoxicity through apoptosis
Sign Up to like & getrecommendations! Published in 2023 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200654
Abstract: New derivatives of 2‐phenylquinazolin‐4(3H)‐one were designed, synthesized, and biologically evaluated as potent allosteric kinase inhibitors with in situ cytotoxicity against MCF‐7 and HepG2 cells. Compounds 15 and 18 among the proposed compounds showed promising antiproliferative… read more here.
Keywords: vegfr; cytotoxicity; apoptosis; phenylquinazolin one ... See more keywords
Design, Synthesis, Structure‐Activity Relationship and Docking Studies of Novel Functionalized Arylvinyl‐1,2,4‐Trioxanes as Potent Antiplasmodial as well as Anticancer Agents
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DOI: 10.1002/cmdc.202000045
Abstract: A novel series of synthetic functionalized arylvinyl‐1,2,4‐trioxanes (8 a–p) has been prepared and assessed for their in vitro antiplasmodial activity against the chloroquine‐resistant Pf INDO strain of Plasmodium falciparum by using a SYBR green‐I fluorescence assay. Compounds… read more here.
Keywords: functionalized arylvinyl; docking studies; arylvinyl trioxanes; ic50 ... See more keywords
A new series of thiazole‐hydrazone hybrids for Akt‐targeted therapy of non‐small cell lung cancer
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.22022
Abstract: In an attempt to identify potent antitumor agents for the fight against non‐small cell lung cancer, new thiazolyl hydrazones (2a–n) were synthesized and examined for their in vitro cytotoxic effects on A549 human lung adenocarcinoma… read more here.
Keywords: cell; non small; ic50; lung ... See more keywords
New pyrrole derivatives as DNA gyrase and 14α-demethylase inhibitors: Design, synthesis, antimicrobial evaluation, and molecular docking.
Sign Up to like & getrecommendations! Published in 2023 at "Drug development research"
DOI: 10.1002/ddr.22080
Abstract: An efficient one-pot reaction utilizing readily available chemical reagents was used to prepare novel 2-amino-1,5-diaryl-1H-pyrrole-3-carbonitrile derivatives and the structures of these compounds were validated by spectroscopic data and elemental analyses. All the synthetic compounds were… read more here.
Keywords: demethylase; dna gyrase; ic50; gyrase demethylase ... See more keywords
Chemistry and anti-herpes simplex virus type 1 evaluation of 4-substituted-1H-1,2,3-triazole-nitroxyl-linked hybrids
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Diversity"
DOI: 10.1007/s11030-020-10094-2
Abstract: HSV disease is distributed worldwide. Anti-herpesvirus drugs are a problem in clinical settings, particularly in immunocompromised individuals undergoing herpes simplex virus type 1 infection. In this work, 4-substituted-1,2,3-1H-1,2,3-triazole linked nitroxyl radical derived from TEMPOL were… read more here.
Keywords: virus type; chemistry; ic50; substituted triazole ... See more keywords
Extracts of Hypsizygus tessellatus (white var.) caps inhibited MCF-7 and MDA-MB-231 cell lines proliferation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Food Measurement and Characterization"
DOI: 10.1007/s11694-018-9952-8
Abstract: Cancer management is associated with serious side-effects due to the harmful nature of radiation and chemotherapy on the body cells. These side-effects have necessitated the need for diversifying the alternative or complementary sources of cancer… read more here.
Keywords: white var; mda; mda 231; ic50 ... See more keywords
Sage (Salvia pilifera): determination of its polyphenol contents, anticholinergic, antidiabetic and antioxidant activities
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Food Measurement and Characterization"
DOI: 10.1007/s11694-019-00127-2
Abstract: In this work, we determined for the first time the Salvia pilifera Montbret & Aucher ex Bentham as an important source for natural products with antioxidant and antidiabetic potentials. In this context, methanol (MESP) and… read more here.
Keywords: mesp wesp; pilifera; salvia pilifera; ic50 ... See more keywords
Seasonal variation in phytochemicals and nutraceutical potential of Begonia nelumbiifolia consumed in Puebla, México
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DOI: 10.1007/s13197-017-2576-x
Abstract: Begonia nelumbiifolia is a traditional edible plant consumed and commercialized in the northern highlands of Puebla, México. The present study reports the seasonal variation in proximate analysis as well as organic acids, carotenoids and flavonoids content… read more here.
Keywords: puebla xico; ic50; seasonal variation; begonia nelumbiifolia ... See more keywords
Diversity and antagonistic potential of Actinobacteria from the fungus-growing termite Odontotermes formosanus
Sign Up to like & getrecommendations! Published in 2019 at "3 Biotech"
DOI: 10.1007/s13205-019-1573-3
Abstract: Abstract43 Actinobacteria were isolated from the nest of Odontotermes formosanus. A phylogenetic analysis of 23 Actinobacteria isolates with different morphotypes showed that they did not form a monophyletic group. Antifungal bioassays exhibited that many strains… read more here.
Keywords: fungus; antagonistic potential; odontotermes formosanus; ic50 ... See more keywords
Synthesis of alpha amylase inhibitors based on privileged indole scaffold.
Sign Up to like & getrecommendations! Published in 2017 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2017.04.010
Abstract: Twenty five derivatives of indole carbohydrazide (1-25) had been synthesized. These compounds were characterized using 1H NMR and EI-MS, and further evaluated for their α-amylase inhibitory potential. The analogs (1-25) showed varying degree of α-amylase… read more here.
Keywords: inhibitory potential; amylase inhibitors; alpha amylase; amylase ... See more keywords