In vitro assessment of the roles of drug transporters in the disposition and drug–drug interaction potential of olaparib
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DOI: 10.1080/00498254.2016.1241449
Abstract: Abstract 1. In vitro assessments were conducted to examine interactions between olaparib (a potent oral inhibitor of poly[ADP-ribose] polymerase) and drug transporters. 2. Olaparib showed inhibition of the hepatic drug uptake transporters OATP1B1 (IC50 values of 20.3 μM… read more here.
Keywords: limited inhibition; inhibition; drug; olaparib ... See more keywords