High anticancer potency on tumor cells of dehydroabietylamine Schiff-base derivatives and a copper(II) complex.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.01.041
Abstract: Five bioactive dehydroabietylamine Schiff-base derivatives (L1-L5) had been synthesized from Dehydroabietylamine (L0), and the complex Cu(L1)2 had been obtained from the compound L1 and copper(II) acetate. Their activities against Hela (cervix), MCF-7 (breast), A549 (lung),… read more here.
Keywords: ic50 value; base derivatives; dehydroabietylamine schiff; cell ... See more keywords
The chemical components of Coreopsis tinctoria Nutt. and their antioxidant, antidiabetic and antibacterial activities
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DOI: 10.1080/14786419.2018.1525377
Abstract: Abstract Seventeen compounds were isolated from the capitula of Coreopsis tinctoria Nutt. with various column chromatographic methods and semi-preparative HPLC. Their structures were identified by the spectroscopic data and comparison with literatures as 2′-hydroxy-4,4′-dimethoxy-chalcone; (1),… read more here.
Keywords: tinctoria nutt; components coreopsis; ic50 value; chemical components ... See more keywords
In vitro Assessment of Total Bioactive Contents, Antioxidant, Anti-Alzheimer and Antidiabetic Activities of Leaves Extracts and Fractions of Aloe vera
Sign Up to like & getrecommendations! Published in 2020 at "Chiang Mai University journal of natural sciences"
DOI: 10.12982/cmujns.2020.0031
Abstract: The present work was conducted to evaluate the quantitative analysis of the leaves of Aloe vera and to evaluate their potential antioxidant, antiAlzheimer and antidiabetic properties in vitro. The acetone extract, methanolic extract and its… read more here.
Keywords: extracts fractions; ic50 value; activity; aloe vera ... See more keywords
Design and preparation of derivatives of oleanolic and glycyrrhetinic acids with cytotoxic properties
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DOI: 10.2147/dddt.s166051
Abstract: Background The structural modification of natural products with the aim to improve the anticancer activity is a popular current research direction. The pentacyclic triterpenoid compounds oleanolic acid (OA) and glycyrrhetinic acid (GA) are distributed widely… read more here.
Keywords: glycyrrhetinic acids; ic50 value; hep cells; compound ... See more keywords
Molecular Docking, Antioxidant, Anticancer and Antileishmanial Effects of Newly Synthesized Quinoline Derivatives.
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DOI: 10.2174/1871520620666200516145117
Abstract: BACKGROUND Due to the need and adverse effects associated with the available anticancer agents, an attempt was made to develop the new anticancer agents with better activity and lesser adverse effects. OBJECTIVE Synthetic approaches based… read more here.
Keywords: ic50 value; anticancer; newly synthesized; quinoline derivatives ... See more keywords
Novel oxadiazole derivatives as potent inhibitors of α-amylase and α-glucosidase enzymes: Synthesis, in vitro evaluation, and molecular docking studies
Sign Up to like & getrecommendations! Published in 2021 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2021.58429.12977
Abstract: Objective(s): Alpha-amylase and alpha-glucosidase enzyme inhibition is an effective and rational approach for controlling postprandial hyperglycemia in type II diabetes mellitus (DM). Several inhibitors of this therapeutic class are in clinical use but are facing… read more here.
Keywords: oxadiazole derivatives; ic50 value; glucosidase; molecular docking ... See more keywords
Anticoagulants as Potential SARS-CoV-2 Mpro Inhibitors for COVID-19 Patients: In Vitro, Molecular Docking, Molecular Dynamics, DFT, and SAR Studies
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DOI: 10.3390/ijms232012235
Abstract: In this article, 34 anticoagulant drugs were screened in silico against the main protease (Mpro) of SARS-CoV-2 using molecular docking tools. Idraparinux, fondaparinux, eptifibatide, heparin, and ticagrelor demonstrated the highest binding affinities towards SARS-CoV-2 Mpro.… read more here.
Keywords: molecular docking; cov mpro; molecular dynamics; potential sars ... See more keywords
Antiprotozoal and Antibacterial Activity of Ravenelin, a Xanthone Isolated from the Endophytic Fungus Exserohilum rostratum
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DOI: 10.3390/molecules26113339
Abstract: The natural compound ravenelin was isolated from the biomass extracts of Exserohilum rostratum fungus, and its antimicrobial, antiplasmodial, and trypanocidal activities were evaluated. Ravenelin was isolated by column chromatography and HPLC and identified by NMR… read more here.
Keywords: ic50 value; activity; exserohilum rostratum; ravenelin ... See more keywords