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   Articles with "ic50 values" as a keyword



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A New Benzophenone and Bioactive Constituents of Hypericum nokoense

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recommendations! Published in 2021 at "Chemistry of Natural Compounds"

DOI: 10.1007/s10600-021-03441-8

Abstract: A new benzophenone derivative, hyperinokone (1), has been isolated from the aerial part of Hypericum nokoense, together with six known compounds. The structure of the new compound 1 was determined through spectroscopic and MS analyses.… read more here.

Keywords: hypericum nokoense; new benzophenone; ic50 values; values respectively ... See more keywords
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Bioactive staurosporine derivatives from the Streptomyces sp. NB-A13.

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recommendations! Published in 2019 at "Bioorganic chemistry"

DOI: 10.1016/j.bioorg.2018.09.016

Abstract: Six new (1-6) and nine known (7-15) staurosporine derivatives were isolated from the rice solid fermentation of the marine-derived Streptomyces sp. NB-A13. The structures of the new staurosporine derivatives were established by extensive spectroscopic data… read more here.

Keywords: staurosporine; derivatives streptomyces; bioactive staurosporine; streptomyces a13 ... See more keywords
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Organometallic and coordination rhenium compounds and their potential in cancer therapy

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recommendations! Published in 2019 at "Coordination Chemistry Reviews"

DOI: 10.1016/j.ccr.2019.04.014

Abstract: Abstract This review focuses on cytotoxic rhenium compounds in terms of IC50 values, their mode of action in biological systems and their status in clinical trials. Biological studies of different rhenium compounds ordered by the… read more here.

Keywords: ic50 values; coordination; rhenium; cancer ... See more keywords
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Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines.

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recommendations! Published in 2017 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2017.02.016

Abstract: The structure of alpha-napthoflavone (ANF), a potent inhibitor of CYP1A1 and CYP1B1, mimics the structure of chalcones. Two potent CYP1B1 inhibitors 7k (DMU2105) and 6j (DMU2139) have been identified from two series of synthetic pyridylchalcones.… read more here.

Keywords: cyp1b1; cyp1b1 inhibitors; ic50 values; cisplatin resistance ... See more keywords
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Towards Computational Prediction of Anti-Cancer Activity: Making Connection between IC50 Values and Metal−Ligand Interaction Energies in some NHC Complexes of Groups 10 and 11

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recommendations! Published in 2021 at "Journal of Molecular Liquids"

DOI: 10.1016/j.molliq.2021.117310

Abstract: Abstract Finding a logical relation between the IC50 values of anticancer drugs and a computationally calculated physical quantity of them can be very useful in predicting and designing new drugs, reduces the time and cost… read more here.

Keywords: interaction energies; ic50; nhc nhc; ic50 values ... See more keywords
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Isoflavones and anti-inflammatory constituents from the fruits of Psoralea corylifolia.

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recommendations! Published in 2017 at "Phytochemistry"

DOI: 10.1016/j.phytochem.2017.08.004

Abstract: The fruits of Psoralea corylifolia, known as Psoraleae Fructus (Buguzhi in Chinese), are traditionally used for the treatment of spermatorrhea, nephritis, asthma, pollakiuria, and various inflammatory diseases. Three previously undescribed isoflavone derivatives, 7-O-methylcorylifol A, 7-O-isoprenylcorylifol… read more here.

Keywords: anti inflammatory; fruits psoralea; psoralea corylifolia; inflammatory constituents ... See more keywords
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Bioactive sesquiterpenoids from the roots of Artabotrys hexapetalus

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recommendations! Published in 2017 at "Tetrahedron"

DOI: 10.1016/j.tet.2016.12.043

Abstract: Abstract Seven pairs of sesquiterpenes (1a/1b–7a/7b), a new peroxy-bridge sesquiterpene (8), and a new peroxy-bridge norsesquiterpene (9), together with five known compounds, were isolated from the roots of Artabotrys hexapetalus. Their structures with absolute configurations… read more here.

Keywords: roots artabotrys; bioactive sesquiterpenoids; sesquiterpenoids roots; ic50 values ... See more keywords
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Reliable identification of cardiac liability in drug discovery using automated patch clamp: Benchmarking best practices and calibration standards for improved proarrhythmic assessment.

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recommendations! Published in 2020 at "Journal of pharmacological and toxicological methods"

DOI: 10.1016/j.vascn.2020.106884

Abstract: INTRODUCTION Screening compounds for activity on the hERG channel using patch clamp is a crucial part of safety testing. Automated patch clamp (APC) is becoming widely accepted as an alternative to manual patch clamp in… read more here.

Keywords: patch clamp; patch; automated patch; reliable identification ... See more keywords
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Small-Molecule Cyanamide Pan-TEAD·YAP1 Covalent Antagonists.

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recommendations! Published in 2022 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.2c01189

Abstract: Transcriptional enhanced associate domains (TEADs) are transcription factors that bind to cotranscriptional activators like the yes-associated protein (YAP) or its paralog transcriptional coactivator with a PDZ-binding motif (TAZ). TEAD·YAP/TAZ target genes are involved in tissue… read more here.

Keywords: small molecule; cyanamide pan; pan tead; tead yap1 ... See more keywords
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Synthesis and Evaluation of 1,3,5-Triaryl-2-Pyrazoline Derivatives as Potent Dual Inhibitors of Urease and α-Glucosidase Together with Their Cytotoxic, Molecular Modeling and Drug-Likeness Studies

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recommendations! Published in 2022 at "ACS Omega"

DOI: 10.1021/acsomega.1c06694

Abstract: In the present work, a concise library of 1,3,5-triaryl-2-pyrazolines (2a–2q) was designed and synthesized by employing a multistep strategy, and the newly synthesized compounds were screened for their urease and α-glucosidase inhibitory activities. The compounds… read more here.

Keywords: dual inhibitors; glucosidase; urease glucosidase; potent dual ... See more keywords

Unravelling the antifungal and antiprotozoal activities and LC-MS/MS quantification of steroidal saponins isolated from Panicum turgidum

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recommendations! Published in 2022 at "RSC Advances"

DOI: 10.1039/d1ra08532h

Abstract: Bioassay-guided investigation of Panicum turgidum extract resulted in the identification of seven steroidal saponins (Turgidosterones 1–7). They were evaluated for their in vitro antifungal, antileishmanial, and antitrypanosomal activities. Turgidosterone 6 was the most active antifungal… read more here.

Keywords: panicum turgidum; steroidal saponins; turgidum; activity ... See more keywords