In Vivo Molecular MRI of ICAM-1 Expression on Endothelium and Leukocytes from Subacute to Chronic Stages After Experimental Stroke
Sign Up to like & getrecommendations! Published in 2017 at "Translational Stroke Research"
DOI: 10.1007/s12975-017-0536-4
Abstract: Molecular MRI allows in vivo detection of vascular cell adhesion molecules expressed on inflamed endothelium, which enables detection of specific targets for anti-neuroinflammatory treatment. We explored to what extent MR contrast agent targeted to intercellular… read more here.
Keywords: icam expression; endothelium; icam mpio; icam ... See more keywords
Epitope-based ligation of ICAM-1: Therapeutic target for protection against the development of rheumatoid arthritis.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.100
Abstract: Identification of a particular epitope on the domain 2 of human ICAM-1 led us to focus on its role in the treatment of rheumatoid arthritis (RA). Key observations from our previous xenotransplantation research included the… read more here.
Keywords: ligation; target; icam; rheumatoid arthritis ... See more keywords
Safety and efficacy of Melissa officinalis (lemon balm) on ApoA-I, Apo B, lipid ratio and ICAM-1 in type 2 diabetes patients: A randomized, double-blinded clinical trial.
Sign Up to like & getrecommendations! Published in 2018 at "Complementary therapies in medicine"
DOI: 10.1016/j.ctim.2018.07.015
Abstract: BACKGROUND The purpose of this study was to investigate the safety and effects of Melissa officinalis, a good source of bioactive components, on apolipoprotein (Apo)B, Apo A-I, and their ratio, lipids ratios and intercellular adhesion… read more here.
Keywords: apo apo; icam; type diabetes; apo ... See more keywords
ICAM-1-mediated adhesion is a prerequisite for exosome-induced T cell suppression.
Sign Up to like & getrecommendations! Published in 2022 at "Developmental cell"
DOI: 10.1016/j.devcel.2022.01.002
Abstract: Tumor-derived extracellular vesicles (TEVs) suppress the proliferation and cytotoxicity of CD8+ T cells, thereby contributing to tumor immune evasion. Here, we report that the adhesion molecule intercellular adhesion molecule 1 (ICAM-1) co-localizes with programmed death ligand… read more here.
Keywords: icam; mediated adhesion; suppression; interaction ... See more keywords
HA of H1N1 enhanced the expression of ICAM-1 and IL-6 in HUVECs and pathological injury in the lungs in mice
Sign Up to like & getrecommendations! Published in 2021 at "Gene"
DOI: 10.1016/j.gene.2021.145854
Abstract: Objective Both COVID-19 and influenza are viral respiratory tract infections and the epidemics of viral respiratory tract infections remain highly prevalent with lethal consequences in susceptible individuals. Expression of ICAM-1 on vascular endothelium recruits leukocytes… read more here.
Keywords: injury lungs; expression icam; icam; pathological injury ... See more keywords
Essential role of ICAM-1 in aldosterone-induced atherosclerosis.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2017.01.013
Abstract: OBJECTIVE Elevated aldosterone is associated with increased risk of atherosclerosis complications, whereas treatment with mineralocorticoid receptor (MR) antagonists decreases the rate of cardiovascular events. Here we test the hypothesis that aldosterone promotes early atherosclerosis by… read more here.
Keywords: icam expression; aldosterone; icam; plaque ... See more keywords
Contribution of intercellular adhesion molecule 1 (ICAM-1) to control Mycobacterium avium infection.
Sign Up to like & getrecommendations! Published in 2017 at "Microbes and infection"
DOI: 10.1016/j.micinf.2017.09.005
Abstract: Mycobacterium avium is a facultative intracellular opportunistic pathogen especially relevant in cases of people living with AIDS. The aim of this study was to evaluate the role of intercellular adhesion molecule 1 (ICAM-1) in the… read more here.
Keywords: infection; avium; avium infection; icam ... See more keywords
Changes in CD200 and intercellular adhesion molecule-1 (ICAM-1) levels in brains of Lewy body disorder cases are associated with amounts of Alzheimer's pathology not α-synuclein pathology
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2017.03.007
Abstract: Enhanced inflammation has been associated with Alzheimer's disease (AD) and diseases with Lewy body (LB) pathology, such as Parkinson's disease (PD) and dementia with Lewy bodies (DLB). One issue is whether amyloid and tangle pathology,… read more here.
Keywords: synuclein pathology; pathology; icam; adhesion molecule ... See more keywords
Ferritin Nanocages with Biologically Orthogonal Conjugation for Vascular Targeting and Imaging.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.8b00004
Abstract: Genetic incorporation of biologically orthogonal functional groups into macromolecules has the potential to yield efficient, controlled, reproducible, site-specific conjugation of affinity ligands, contrast agents, or therapeutic cargoes. Here, we applied this approach to ferritin, a… read more here.
Keywords: targeting imaging; vascular targeting; ferritin; icam ... See more keywords
Molecular Targeting of Immunosuppressants Using a Bi-functional Elastin-Like Polypeptide.
Sign Up to like & getrecommendations! Published in 2019 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.9b00462
Abstract: Elastin-Like Polypeptides (ELP) are environmentally-responsive protein polymers which are easy to engineer and biocompatible, making them ideal candidates as drug carriers. Our team has recently utilized ELPs fused to FKBP12 to carry Rapamycin (Rapa), a… read more here.
Keywords: rapa; male nod; molecular targeting; elastin like ... See more keywords
Investigation of ICAM-1 levels in hypertensive patients with fragmented QRS complexes
Sign Up to like & getrecommendations! Published in 2019 at "Acta Cardiologica"
DOI: 10.1080/00015385.2018.1555200
Abstract: Abstract Objective: Fragmented QRS (fQRS) detected on a 12-lead electrocardiogram (ECG) has been demonstrated to be a marker of myocardial fibrosis. Intercellular adhesion molecule-1 (ICAM-1) is a protein which plays an important role in fibro-inflammatory… read more here.
Keywords: presence fqrs; icam; hypertensive patients; icam levels ... See more keywords