Icariin protects against iron overload‐induced bone loss via suppressing oxidative stress
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27678
Abstract: Iron overload is common in patients with diseases such as hemoglobinopathies, hereditary hemochromatosis or elderly men and postmenopausal women. This disorder is frequently associated with bone loss and recently has been considered as an independent… read more here.
Keywords: icariin; iron overload; overload induced; bone loss ... See more keywords
Porous composite scaffold incorporating osteogenic phytomolecule icariin for promoting skeletal regeneration in challenging osteonecrotic bone in rabbits.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.10.025
Abstract: Steroid-associated osteonecrosis (SAON) often requires surgical core decompression (CD) in the early stage for removal of necrotic bone to facilitate repair where bone grafts are needed for filling bone defect and avoiding subsequent joint collapse.… read more here.
Keywords: pti scaffold; composite scaffold; icariin; scaffold ... See more keywords
The cardioprotective effects of icariin on the isoprenaline-induced takotsubo-like rat model: Involvement of reactive oxygen species and the TLR4/NF-κB signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.105733
Abstract: INTRODUCTION Takotsubo syndrome (TS) is an acute cardiac syndrome that mimics acute coronary syndrome (ACS) but lacks coronary obstruction and is associated with sudden physical or psychiatric episodes. Several hypotheses have been proposed for the… read more here.
Keywords: reactive oxygen; icariin; oxygen species; signaling pathway ... See more keywords
Study on the regulatory mechanism and experimental verification of icariin for the treatment of ovarian cancer based on network pharmacology.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.113189
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Herba Epimedii (Berberidaceae) has the advantages of "nourishing the kidney and reinforcing the Yang". Many species in this genus have long been used in traditional Chinese medicine (TCM) and have been used as… read more here.
Keywords: medicine; network; icariin; mechanism ... See more keywords
Microbial transformation of icariin and its derivatives.
Sign Up to like & getrecommendations! Published in 2021 at "Natural product research"
DOI: 10.1080/14786419.2021.1975702
Abstract: Microbial transformation is an important tool to perform selective conversion of compounds to derivatives which are difficult to produce synthetically. In order to obtain icariside II and icaritin, the active components in Herba Epimedii in… read more here.
Keywords: microbial transformation; transformation icariin; icariin; icaritin ... See more keywords
Icariin improves SHR erectile function via inhibiting eNOS uncoupling
Sign Up to like & getrecommendations! Published in 2018 at "Andrologia"
DOI: 10.1111/and.13084
Abstract: The aim of the study was to investigate whether or not the effect of icariin on erectile function of SHR is associated with inhibition of eNOS uncoupling. Ten 12‐week‐old male WKY rats and 10 age‐matched… read more here.
Keywords: enos uncoupling; erectile function; icariin; group ... See more keywords
Effect of icariin on the H2O2-induced proliferation of mouse airway smooth muscle cells through miR-138-5p regulating SIRT1/AMPK/PGC-1α axis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Immunopathology and Pharmacology"
DOI: 10.1177/03946320231151515
Abstract: Icariin exerts antioxidative and anti-inflammatory effects and is used in the treatment of bronchial asthma. However, the specific modes of action are uncertain. In this study, we investigated whether icariin could modulate the silencing information… read more here.
Keywords: icariin; proliferation; h2o2 induced; mir 138 ... See more keywords
Human Safety and Pharmacokinetics Study of Orally Administered Icariin: Randomized, Double-Blind, Placebo-Controlled Trial
Sign Up to like & getrecommendations! Published in 2019 at "Natural Product Communications"
DOI: 10.1177/1934578x19856789
Abstract: Preclinical literature suggests that icariin, a flavonoid found in Epimedium, may have potential for medical and psychiatric conditions. The objective of this study was to examine the safety, tolerability, and pharmacokinetics of orally administered icariin… read more here.
Keywords: administered icariin; placebo; human safety; orally administered ... See more keywords
The antiosteoporosis effect of icariin in ovariectomized rats: a systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and molecular biology"
DOI: 10.14715/cmb/2017.63.11.22
Abstract: Herba Epimedii (Yinyanghuo or Horny Goat Weed) is a traditional Chinese medicine widely used in treating osteoporosis. As the major active component, icariin is intensively investigated in the prevention and treatment of osteoporosis in ovariectomized… read more here.
Keywords: icariin; review meta; ovariectomized rats; icariin ovariectomized ... See more keywords
Icariin stimulates differentiation of bone marrow-derived mesenchymal stem cells (BM-MSCs) through activation of cAMP/PKA/CREB
Sign Up to like & getrecommendations! Published in 2019 at "Brazilian Journal of Pharmaceutical Sciences"
DOI: 10.1590/s2175-97902019000218300
Abstract: Icariin, a prenylated flavonol glycoside isolated from Epimedium, has been considered as a potential alternative therapy for osteoporosis. The present study aimed to clarify the detailed molecular mechanisms of action of icariin on osteoblast function,… read more here.
Keywords: creb; camp pka; pka creb; icariin ... See more keywords
Icariin and Competing Endogenous RNA Network: A Potential Protective Strategy Against Contrast-Induced Acute Kidney Injury
Sign Up to like & getrecommendations! Published in 2022 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s369100
Abstract: Background Icariin presents protective effect in several kidney diseases. However, the role of icariin in contrast-induced acute kidney injury (CIAKI) is still unclear. This study aimed to investigate the effect of icariin in CIAKI, as… read more here.
Keywords: network; icariin; kidney; contrast induced ... See more keywords