Renal transporter OAT1 and PPAR‐α pathway co‐contribute to icaritin‐induced nephrotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7633
Abstract: This study aimed to investigate the potential nephrotoxicity of icaritin and the underlying mechanism by in vitro–in vivo experiment technology combined with proteomics technology. First, icaritin showed a significant cytotoxic effect on HK‐2 cells, which… read more here.
Keywords: ppar; icaritin induced; renal transporter; icaritin ... See more keywords
PPARγ mediates the anti-pulmonary fibrosis effect of icaritin.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2021.06.014
Abstract: BACKGROUND Pulmonary fibrosis is a fatal lung disease with limited treatment options. Icaritin is the active ingredient derived from the traditional Chinese medical plant Epimedium and possesses many biomedical activities. This study aimed to investigate… read more here.
Keywords: collagen; ppar; icaritin; expression ... See more keywords
Co-Immobilizing Two Glycosidases Based on Cross-Linked Enzyme Aggregates to Enhance Enzymatic Properties for Achieving High Titer Icaritin Biosynthesis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c04253
Abstract: Icaritin is a rare and high-value isopentane flavonoid compound with remarkable activities. Increasing yields while reducing cost has been a great challenge in icaritin production. Herein, we first reported a high titer icaritin biosynthesis strategy… read more here.
Keywords: cross linked; high titer; titer icaritin; linked enzyme ... See more keywords
An icaritin-loaded microemulsion based on coix oil for improved pharmacokinetics and enhanced antitumor efficacy
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2147601
Abstract: Abstract Combinational icaritin (IC) and coix seed oil (CSO) holds promising potential in the treatment of hepatocellular carcinoma. However, traditional cocktail therapy is facing difficulties to optimize the synergistic antitumor efficacy due to the asynchronous… read more here.
Keywords: microemulsion; oil; coix oil; icaritin ... See more keywords
Microbial transformation of icariin and its derivatives.
Sign Up to like & getrecommendations! Published in 2021 at "Natural product research"
DOI: 10.1080/14786419.2021.1975702
Abstract: Microbial transformation is an important tool to perform selective conversion of compounds to derivatives which are difficult to produce synthetically. In order to obtain icariside II and icaritin, the active components in Herba Epimedii in… read more here.
Keywords: microbial transformation; transformation icariin; icariin; icaritin ... See more keywords
Regio-selective synthesis and activity research on 7-icaritin norcantharidin conjugates.
Sign Up to like & getrecommendations! Published in 2022 at "Natural product research"
DOI: 10.1080/14786419.2022.2121828
Abstract: Due to complexity of tumor diseases and resistance of targeted drug, targeted drug usually cannot meet the needs of cancer treatment. Therefore, the conjugate constructed by two anticancer agents maybe a better solution for the… read more here.
Keywords: selective synthesis; synthesis activity; icaritin; regio selective ... See more keywords
Mechanistic Study of Icaritin-Induced Inactivation of Cytochrome P450 2C9
Sign Up to like & getrecommendations! Published in 2023 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.122.001245
Abstract: Icaritin (ICT) is a prenylflavonoid derivative that has been approved by National Medical Products Administration for the treatment of hepatocellular carcinoma. This study aims to evaluate the potential inhibitory effect of ICT against cytochrome P450… read more here.
Keywords: ict; cyp2c9; icaritin; drug ... See more keywords
AMPK-autophagy inhibition sensitizes icaritin-induced anti-colorectal cancer cell activity
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14718
Abstract: The current research studied the potential effect of autophagy on icaritin-induced anti-colorectal cancer (CRC) cell activity. Treatment of icaritin in both primary and established (HT-29) CRC cells induced feedback activation of autophagy, evidenced by p62… read more here.
Keywords: icaritin induced; icaritin; ampk; induced anti ... See more keywords
Icaritin Induces Anti-tumor Immune Responses in Hepatocellular Carcinoma by Inhibiting Splenic Myeloid-Derived Suppressor Cell Generation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.609295
Abstract: Recent studies have demonstrated that splenic extramedullary hematopoiesis (EMH) is an important mechanism for the accumulation of myeloid-derived suppressor cells (MDSCs) in tumor tissues, and thus contributes to disease progression. Icaritin, a prenylflavonoid derivative from… read more here.
Keywords: hcc; icaritin; generation; anti tumor ... See more keywords
Down-regulation of microRNA-10a mediates the anti-tumor effect of icaritin in A549 cells via the PTEN/AKT and ERK pathway.
Sign Up to like & getrecommendations! Published in 2019 at "General physiology and biophysics"
DOI: 10.4149/gpb_2019041
Abstract: Icaritin, a prenylflavonoid derivative from Epimedium Genus, has been reported to exhibit tumor inhibitory effects on many types of tumor cells. Numerous studies have demonstrated that microRNAs (miRs) involve in the biological process of carcinogenesis… read more here.
Keywords: a549 cells; icaritin; anti tumor; mir 10a ... See more keywords