Renal transporter OAT1 and PPAR‐α pathway co‐contribute to icaritin‐induced nephrotoxicity
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DOI: 10.1002/ptr.7633
Abstract: This study aimed to investigate the potential nephrotoxicity of icaritin and the underlying mechanism by in vitro–in vivo experiment technology combined with proteomics technology. First, icaritin showed a significant cytotoxic effect on HK‐2 cells, which… read more here.
Keywords: ppar; icaritin induced; renal transporter; icaritin ... See more keywords
AMPK-autophagy inhibition sensitizes icaritin-induced anti-colorectal cancer cell activity
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DOI: 10.18632/oncotarget.14718
Abstract: The current research studied the potential effect of autophagy on icaritin-induced anti-colorectal cancer (CRC) cell activity. Treatment of icaritin in both primary and established (HT-29) CRC cells induced feedback activation of autophagy, evidenced by p62… read more here.
Keywords: icaritin induced; icaritin; ampk; induced anti ... See more keywords