The HPV16 E6, E7/miR-23b-3p/ICAT signaling axis promotes proliferation, migration, invasion and EMT of cervical cancer cells.
Sign Up to like & getrecommendations! Published in 2023 at "Carcinogenesis"
DOI: 10.1093/carcin/bgad008
Abstract: Cervical cancer (CC) remains one of the most common female malignancies, with higher incidence and mortality rates. more than 99% of cervical cancers are associated with persistent infection with high-risk human papillomavirus. In view of… read more here.
Keywords: cervical cancer; expression; hpv16; icat ... See more keywords
Expression level and prognostic potential of beta-catenin–interacting protein in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000030022
Abstract: Inhibitor of beta-catenin and TCF (ICAT) is a key protein in the Wnt-β-catenin signaling pathway. However, its role in acute myeloid leukemia (AML) remains unknown. In this study, we evaluated its expression level as well… read more here.
Keywords: beta catenin; myeloid leukemia; expression; acute myeloid ... See more keywords
iCAT: diagnostic assessment tool of immunological history using high-throughput T-cell receptor sequencing
Sign Up to like & getrecommendations! Published in 2021 at "F1000Research"
DOI: 10.12688/f1000research.27214.2
Abstract: The pathogen exposure history of an individual is recorded in their T-cell repertoire and can be accessed through the study of T-cell receptors (TCRs) if the tools to identify them were available. For each T-cell,… read more here.
Keywords: tcr sequencing; tool; immunological history; icat ... See more keywords
Structure-based mutational analysis of ICAT residues mediating negative regulation of β-catenin co-transcriptional activity
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DOI: 10.1371/journal.pone.0172603
Abstract: ICAT (Inhibitor of β-CAtenin and TCF) is a small acidic protein that negatively regulates β-catenin co-transcriptional activity by competing with TCF/LEF factors in their binding to β-catenin superhelical core. In melanoma cells, ICAT competes with… read more here.
Keywords: catenin; icat residues; transcriptional activity; icat ... See more keywords
Inhibitor of β-catenin and TCF (ICAT) promotes cervical cancer growth and metastasis by disrupting E-cadherin/β-catenin complex
Sign Up to like & getrecommendations! Published in 2017 at "Oncology Reports"
DOI: 10.3892/or.2017.5962
Abstract: The inhibitor of β-catenin and TCF (ICAT) blocks the binding of TCF to β-catenin and has been demonstrated as a suppressor of the Wnt/β-catenin signaling pathway. It has been reported to exert a different function… read more here.
Keywords: tcf; inhibitor catenin; catenin; cervical cancer ... See more keywords