Structure-based mutational analysis of ICAT residues mediating negative regulation of β-catenin co-transcriptional activity
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DOI: 10.1371/journal.pone.0172603
Abstract: ICAT (Inhibitor of β-CAtenin and TCF) is a small acidic protein that negatively regulates β-catenin co-transcriptional activity by competing with TCF/LEF factors in their binding to β-catenin superhelical core. In melanoma cells, ICAT competes with… read more here.
Keywords: catenin; icat residues; transcriptional activity; icat ... See more keywords