Akutbehandlung der intrazerebralen Blutung
Sign Up to like & getrecommendations! Published in 2019 at "Medizinische Klinik - Intensivmedizin und Notfallmedizin"
DOI: 10.1007/s00063-019-00607-9
Abstract: Die intrazerebrale Blutung (ICB) ist eine der schwersten Schlaganfallformen und vergesellschaftet mit einer hohen Morbidität sowie Mortalität. Allerdings gibt es bislang keine effektiven Therapiestrategien, die den funktionellen Zustand nachhaltig verbessern. Dieser Übersichtsbeitrag evaluiert aktuelle Entwicklungen… read more here.
Keywords: icb; die; akutbehandlung; der ... See more keywords
Local and Targeted Delivery of Immune Checkpoint Blockade Therapeutics.
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DOI: 10.1021/acs.accounts.0c00339
Abstract: ConspectusImmune checkpoint blockade (ICB) therapy elicits antitumor response by inhibiting immune suppressor components, including programmed cell death protein 1 and its ligand (PD-1/PD-L1) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). Despite improved therapeutic efficacy, the clinical… read more here.
Keywords: checkpoint blockade; icb; local targeted; delivery ... See more keywords
Thermosensitive Hydrogel Sustaining the Release of Lymph-Draining Oligonucleotide Adjuvant Polyplex Micelles Improves Systemic Cancer Immunotherapy
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DOI: 10.1021/acsnano.5c05517
Abstract: Immune checkpoint blockade (ICB) immunotherapies are a powerful tool in the clinical management of cancer, but response rates to ICB remain limited, and treatment-related toxicities can be significant. Therapeutic efficacy of ICB can be enhanced… read more here.
Keywords: lymph; release; icb; oligonucleotide adjuvant ... See more keywords
CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors
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DOI: 10.1038/s41586-024-07943-7
Abstract: For patients with advanced non-small-cell lung cancer (NSCLC), dual immune checkpoint blockade (ICB) with CTLA4 inhibitors and PD-1 or PD-L1 inhibitors (hereafter, PD-(L)1 inhibitors) is associated with higher rates of anti-tumour activity and immune-related toxicities,… read more here.
Keywords: resistance; dual icb; blockade; keap1 stk11 ... See more keywords
PPP2R1A mutations portend improved survival after cancer immunotherapy
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DOI: 10.1038/s41586-025-09203-8
Abstract: Immune checkpoint blockade (ICB) therapy is effective against many cancers, although resistance remains a major issue and new strategies are needed to improve clinical outcomes1, 2, 3, 4–5. Here we studied ICB response in a… read more here.
Keywords: cancer; survival; improved survival; icb ... See more keywords
Peptide nano ‘bead-grafting’ for SDT-facilitated immune checkpoints blocking
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc02728c
Abstract: Combination therapies based on immune checkpoint blockade (ICB) are currently the mainstay of cancer treatment, in which the synergetic delivery of multiple drugs is the essential step. Although nanoparticle drugs (NPDs) show satisfactory anticancer effects,… read more here.
Keywords: bead grafting; icb; nano bead; immune checkpoints ... See more keywords
Neoadjuvant immune checkpoint blockade triggers persistent and systemic Treg activation which blunts therapeutic efficacy against metastatic spread of breast tumors
Sign Up to like & getrecommendations! Published in 2023 at "Oncoimmunology"
DOI: 10.1080/2162402x.2023.2201147
Abstract: ABSTRACT The clinical successes of immune checkpoint blockade (ICB) in advanced cancer patients have recently spurred the clinical implementation of ICB in the neoadjuvant and perioperative setting. However, how neoadjuvant ICB therapy affects the systemic… read more here.
Keywords: icb; immune checkpoint; breast; tumor ... See more keywords
GRANZYME A-PRODUCING CD4 T CELLS ARE DRIVERS OF IMMUNE CHECKPOINT BLOCKADE-INDUCED COLITIS
Sign Up to like & getrecommendations! Published in 2024 at "Inflammatory Bowel Diseases"
DOI: 10.1093/ibd/izae020.122
Abstract: Immune checkpoint blockade (ICB) (i.e. anti-CTLA4 and/or anti-PD-1) is a type of cancer immunotherapy that is broadly and effectively used across multiple cancer types. Despite this efficacy, ~60% of individuals of ICB recipients develop autoimmune-like… read more here.
Keywords: cd4 cells; cell; icb; cd4 ... See more keywords
CTIM-12. DUAL IMMUNE CHECKPOINT BLOCKADE FOR SURGICALLY ACCESSIBLE RECURRENT GLIOBLASTOMA: CLINICAL AND MOLECULAR OUTCOMES
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.0469
Abstract: Our previous study of neoadjuvant PD-1 immune checkpoint blockade (ICB) in surgically-accessible recurrent glioblastoma suggested that single-agent PD-1 blockade induced adaptive immune responses that may have paradoxically inhibited functional anti-tumor immune responsiveness. To address this,… read more here.
Keywords: dual icb; immune checkpoint; glioblastoma; checkpoint blockade ... See more keywords
Blood and guts: peripheral immune correlates of immunotherapy‐induced colitis
Sign Up to like & getrecommendations! Published in 2022 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12604
Abstract: Toxicity remains a major limitation of immune checkpoint blockade (ICB) in cancer treatment, and is likely to become increasingly problematic as treatment indications broaden and novel combinations progress. ICB-induced immunerelated adverse events (irAEs) in the… read more here.
Keywords: icb; icb induced; induced colitis; colitis ... See more keywords
Pharmacological activation of STAT1-GSDME pyroptotic circuitry reinforces epigenetic immunotherapy for hepatocellular carcinoma
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DOI: 10.1136/gutjnl-2024-332281
Abstract: Background Genomic screening uncovered interferon-gamma (IFNγ) pathway defects in tumours refractory to immune checkpoint blockade (ICB). However, its non-mutational regulation and reversibility for therapeutic development remain less understood. Objective We aimed to identify ICB resistance-associated… read more here.
Keywords: hepatocellular carcinoma; icb; stat1 gsdme; gsdme ... See more keywords