Akutbehandlung der intrazerebralen Blutung
Sign Up to like & getrecommendations! Published in 2019 at "Medizinische Klinik - Intensivmedizin und Notfallmedizin"
DOI: 10.1007/s00063-019-00607-9
Abstract: Die intrazerebrale Blutung (ICB) ist eine der schwersten Schlaganfallformen und vergesellschaftet mit einer hohen Morbidität sowie Mortalität. Allerdings gibt es bislang keine effektiven Therapiestrategien, die den funktionellen Zustand nachhaltig verbessern. Dieser Übersichtsbeitrag evaluiert aktuelle Entwicklungen… read more here.
Keywords: icb; die; akutbehandlung; der ... See more keywords
Local and Targeted Delivery of Immune Checkpoint Blockade Therapeutics.
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DOI: 10.1021/acs.accounts.0c00339
Abstract: ConspectusImmune checkpoint blockade (ICB) therapy elicits antitumor response by inhibiting immune suppressor components, including programmed cell death protein 1 and its ligand (PD-1/PD-L1) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). Despite improved therapeutic efficacy, the clinical… read more here.
Keywords: checkpoint blockade; icb; local targeted; delivery ... See more keywords
Peptide nano ‘bead-grafting’ for SDT-facilitated immune checkpoints blocking
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DOI: 10.1039/d2sc02728c
Abstract: Combination therapies based on immune checkpoint blockade (ICB) are currently the mainstay of cancer treatment, in which the synergetic delivery of multiple drugs is the essential step. Although nanoparticle drugs (NPDs) show satisfactory anticancer effects,… read more here.
Keywords: bead grafting; icb; nano bead; immune checkpoints ... See more keywords
Neoadjuvant immune checkpoint blockade triggers persistent and systemic Treg activation which blunts therapeutic efficacy against metastatic spread of breast tumors
Sign Up to like & getrecommendations! Published in 2023 at "Oncoimmunology"
DOI: 10.1080/2162402x.2023.2201147
Abstract: ABSTRACT The clinical successes of immune checkpoint blockade (ICB) in advanced cancer patients have recently spurred the clinical implementation of ICB in the neoadjuvant and perioperative setting. However, how neoadjuvant ICB therapy affects the systemic… read more here.
Keywords: icb; immune checkpoint; breast; tumor ... See more keywords
Blood and guts: peripheral immune correlates of immunotherapy‐induced colitis
Sign Up to like & getrecommendations! Published in 2022 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12604
Abstract: Toxicity remains a major limitation of immune checkpoint blockade (ICB) in cancer treatment, and is likely to become increasingly problematic as treatment indications broaden and novel combinations progress. ICB-induced immunerelated adverse events (irAEs) in the… read more here.
Keywords: icb; icb induced; induced colitis; colitis ... See more keywords
Abstract 1393: Persistent mutation burden drives sustained anti-tumor immune responses in human cancers
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DOI: 10.1158/1538-7445.am2023-1393
Abstract: INTRODUCTION: Tumor mutation burden (TMB) is a commonly used biomarker for cancer immunotherapy however TMB only partially captures tumor foreignness. We hypothesized that mutations in single-copy regions of the genome or mutations present in multiple… read more here.
Keywords: icb; mutation burden; persistent mutations; tumor ... See more keywords
Abstract 3279: Systemic immune response invoked by short-course oxaliplatin-based chemotherapy (FLOX) for efficacy of sequential immune checkpoint blockade (ICB; nivolumab) in microsatellite-stable (MSS) metastatic colorectal cancer (mCRC)
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3279
Abstract: Purpose: Most mCRC patients harbor MSS disease without inherent immunogenicity. The METIMMOX study (NCT03388190) explored an unconventional concept, that patients with previously untreated, unresectable abdominal metastases from MSS-CRC may achieve therapeutic efficacy from short-course oxaliplatin-based… read more here.
Keywords: short course; icb; chemotherapy; response ... See more keywords
Abstract 5170: STING inflames NF1 malignancies for immunotherapy
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DOI: 10.1158/1538-7445.am2023-5170
Abstract: Introduction: Neurofibromatosis Type 1 (NF1) is caused by mutations in the NF1 gene that encodes neurofibromin, a RAS GTPase-Activating Protein. Inactivating NF1 mutations result in hyperactivation of RAS-mediated signaling. NF1 patients develop benign tumors on… read more here.
Keywords: cell; sting agonist; icb; sting inflames ... See more keywords
Abstract 5472: Utilizing response in immune checkpoint inhibitor treated cohorts improves clinical applicability of neoantigen immunogenicity predictions
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DOI: 10.1158/1538-7445.am2023-5472
Abstract: Introduction: Neoantigen-based biomarkers have improved predictions of response to immune checkpoint blockade (ICB) therapy, highlighting the importance of accurate prediction of immunogenic neoantigen candidates. A challenge in developing robust immunogenicity prediction models is limited availability… read more here.
Keywords: response immune; icb; immune checkpoint; neoantigen ... See more keywords
Abstract 6046: Enhanced Acod1 expression in cancer cells promotes immune evasion
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6046
Abstract: The monoclonal antibody αPD-1 used in immune checkpoint blockade (ICB) therapy has made a substantial impact in clinical outcomes for melanoma, lung, and breast cancer patients. Despite the success of ICB in these contexts, such… read more here.
Keywords: cell; cancer; icb; expression ... See more keywords
Abstract 6409: Non-redundant mechanisms of immune resistance to radiotherapy converge on innate immunity
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6409
Abstract: Multiple studies have demonstrated synergy between immune checkpoint blockade (ICB) and radiotherapy (RT) in preclinical murine models; however, randomized trials of RT/ICB have been inconsistent in patients with solid tumors. To better understand this discordance,… read more here.
Keywords: icb; non redundant; cd47; resistance ... See more keywords