Editorial for “Comparing Survival Outcomes of Patients With LI‐RADS‐M Hepatocellular Carcinomas and Intrahepatic Cholangiocarcinomas”
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.28222
Abstract: Editorial for “Comparing Survival Outcomes of Patients With LI-RADS-M Hepatocellular Carcinomas and Intrahepatic Cholangiocarcinomas” Hepatocellular carcinoma (HCC) is the most common primary liver cancer followed by intrahepatic cholangiocarcinoma (iCCA) and combined HCC-CCA (cHCC-CCA). Once HCC… read more here.
Keywords: icca; survival; hccs; hcc ... See more keywords
SOX9 expression decreases survival of patients with intrahepatic cholangiocarcinoma by conferring chemoresistance
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Cancer"
DOI: 10.1038/s41416-018-0338-9
Abstract: BackgroundSex-determining region Y-box (SRY-box) containing gene 9 (SOX9) expression confers cancer stem cell features. However, SOX9 function in intrahepatic cholangiocarcinoma (iCCA) is unknown. This study investigated the effects and underlying mechanisms of SOX9 in iCCA.MethodsSOX9… read more here.
Keywords: icca; expression decreases; sox9 expression; intrahepatic cholangiocarcinoma ... See more keywords
UCK2 promotes intrahepatic cholangiocarcinoma progression and desensitizes cisplatin treatment by PI3K/AKT/mTOR/autophagic axis
Sign Up to like & getrecommendations! Published in 2024 at "Cell Death Discovery"
DOI: 10.1038/s41420-024-02140-x
Abstract: Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive tumor with extremely poor prognosis due to the low resection rate, high recurrence rate and drug resistance. Uridine-cytidine kinase 2 (UCK2) is proved to promote progression and drug… read more here.
Keywords: akt mtor; progression; icca; mtor autophagic ... See more keywords
Targeting FGFR in intrahepatic cholangiocarcinoma [iCCA]: leading the way for precision medicine in biliary tract cancer [BTC]?
Sign Up to like & getrecommendations! Published in 2021 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2021.1900821
Abstract: ABSTRACT Introduction: The increasing availability of next-generation DNA sequencing (NGS) opens the opportunity to tailor therapies to potential targets. Intrahepatic cholangiocarcinoma (iCCA) has the most actionable genomic targets of the hepatobiliary malignancies, including mutations in… read more here.
Keywords: medicine; icca; intrahepatic cholangiocarcinoma; cholangiocarcinoma icca ... See more keywords
Management of intrahepatic cholangiocarcinoma: a review for clinicians
Sign Up to like & getrecommendations! Published in 2025 at "Gastroenterology Report"
DOI: 10.1093/gastro/goaf005
Abstract: Abstract Intrahepatic cholangiocarcinoma (iCCA) is an aggressive liver malignancy that arises from second-order biliary epithelial cells. Its incidence is gradually increasing worldwide. Well-known risk factors have been described, although in many cases, they are not… read more here.
Keywords: treatment; review; icca; management intrahepatic ... See more keywords
Intracavitary Coronary Artery
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thoracic Imaging"
DOI: 10.1097/rti.0000000000000418
Abstract: Purpose: A few case reports of intracavitary coronary arteries (ICCA) have been reported and only a single case series on the coronary computed tomography angiography (CCTA) prevalence rate of ICCA of the right coronary artery… read more here.
Keywords: intracavitary coronary; prevalence rate; coronary artery; prevalence ... See more keywords
Immunosuppressive contribution of tumour-infiltrating B cells in human intrahepatic cholangiocarcinoma and their role in chemoimmunotherapy outcome
Sign Up to like & getrecommendations! Published in 2025 at "Gut"
DOI: 10.1136/gutjnl-2025-334861
Abstract: Background Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive biliary tract cancer with a poor prognosis and a complex tumour microenvironment (TME) that remains poorly understood. Objective This study aimed to investigate the phenotypic and molecular… read more here.
Keywords: tumour infiltrating; icca; chemoimmunotherapy; intrahepatic cholangiocarcinoma ... See more keywords
FGFR2 Inhibition in Cholangiocarcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of medicine"
DOI: 10.1146/annurev-med-042921-024707
Abstract: Biliary tract cancer (BTC) is the second most common primary liver cancer after hepatocellular carcinoma and accounts for 2% of cancer-related deaths. BTCs are classified according to their anatomical origin into intrahepatic (iCCA), perihilar, or… read more here.
Keywords: inhibition cholangiocarcinoma; icca; fgfr2 inhibition; medicine ... See more keywords
Combined Inhibition of Smoothened and the DNA Damage Checkpoint WEE1 Exerts Antitumor Activity in Cholangiocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-22-0379
Abstract: Abstract Cholangiocarcinoma (CCA) is characterized by resistance to chemotherapy and a poor prognosis. Therefore, treatments that can effectively suppress tumor growth are urgently needed. Aberrant activation of hedgehog (HH) signaling has been implicated in several… read more here.
Keywords: inhibition; icca; dna damage; wee1 ... See more keywords
Abstract 5806: Kinase library screening identifies IGF-1R/PI3K/AKT axis as a crucial pathway for survival of intrahepatic cholangiocarcinoma cells with stemness characteristics
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5806
Abstract: Intrahepatic cholangiocarcinoma (iCCA) is a subtype of biliary malignancy that arises along the peripheral bile duct epithelium. Given its limited and inefficacious treatment options, the mortality rate of iCCA remains high and thus a novel… read more here.
Keywords: stemness characteristics; intrahepatic cholangiocarcinoma; icca; akt axis ... See more keywords
Updated results of the FOENIX-CCA2 trial: Efficacy and safety of futibatinib in intrahepatic cholangiocarcinoma (iCCA) harboring FGFR2 fusions/rearrangements.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2022.40.16_suppl.4009
Abstract: 4009 Background: Survival outcomes are historically poor in patients (pts) with advanced/metastatic iCCA, with median overall survival (mOS) times of approximately 1 year with first-line gemcitabine plus cisplatin and approximately 6 months with second-line chemotherapy.… read more here.
Keywords: safety; icca harboring; icca; analysis ... See more keywords