Efficient Synthesis of Icetexane Diterpenes and Apoptosis Inducing Effect by Upregulating BiP-ATF4-CHOP Axis in Colorectal Cells.
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DOI: 10.1021/acs.jnatprod.1c00310
Abstract: We herein present an efficient and robust synthetic strategy toward 12 icetexane diterpenes and their derivatives, which features a PPh3/DIAD-mediated rearrangement of the reduced carnosic acid derivative (2) to give (-)-barbatusol (3) in a regioselective… read more here.
Keywords: atf4 chop; icetexane diterpenes; bip atf4;