Abstract 2886: Investigation of tumor-intrinsic activated Wnt/B-catenin signaling in immune avoidance of HCC
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DOI: 10.1158/1538-7445.am2023-2886
Abstract: Background: Recent evidence have indicated several tumor-intrinsic oncogene pathways in T cell exclusion and immune evasion of cancers . In hepatocellular carcinoma (HCC), Wnt/β-catenin (CTNNB1) signaling activation is highly prevalent and has been reported to… read more here.
Keywords: wnt catenin; hcc; icg 001; ctnnb1 ... See more keywords
Abstract B26: Prometastatic effect of ICG-001, a β-catenin/CBP dependent transcription inhibitor, in osteosarcoma
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DOI: 10.1158/1538-7445.pedca19-b26
Abstract: Osteosarcoma is the most common malignant bone tumor in the pediatric population, representing around 4 cases per million people per year in the world. Patient survival is closely related to the response of tumor cells… read more here.
Keywords: catenin cbp; catenin; osteosarcoma; effect ... See more keywords
Effective Reconstruction of Functional Urethra Promoted With ICG-001 Delivery Using Core-Shell Collagen/Poly(Llactide-co-caprolactone) [P(LLA-CL)] Nanoyarn-Based Scaffold: A Study in Dog Model
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2020.00774
Abstract: Hypospadias and urethral stricture are common urological diseases which seriously affect voiding function and life quality of the patients, yet current clinical treatments often result in unsatisfactory clinical outcome with frequent complications. In vitro experiments… read more here.
Keywords: icg 001; study; functional urethra; dog model ... See more keywords
Metformin and ICG-001 Act Synergistically to Abrogate Cancer Stem Cells-Mediated Chemoresistance in Colorectal Cancer by Promoting Apoptosis and Autophagy
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DOI: 10.3390/cancers14051281
Abstract: Simple Summary Colorectal cancer (CRC) is one of the most frequently diagnosed and lethal malignancies. The majority of CRC patients experience disease relapse after the primary curative treatment strategy of surgery followed by 5FU-based chemotherapy.… read more here.
Keywords: metformin icg; crc; icg 001; cancer ... See more keywords
Selective Inhibition of β-Catenin/Co-Activator Cyclic AMP Response Element-Binding Protein-Dependent Signaling Prevents the Emergence of Hapten-Induced Atopic Dermatitis-Like Dermatitis
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DOI: 10.5021/ad.2019.31.6.631
Abstract: Background The canonical Wnt/β-catenin signaling pathway is a fundamental regulatory system involved in various biological events. ICG-001 selectively blocks the interaction of β-catenin with its transcriptional co-activator cyclic AMP response element-binding protein (CBP). Recent studies… read more here.
Keywords: catenin; activator cyclic; like dermatitis; icg 001 ... See more keywords