Articles with "ich s7b" as a keyword



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Determination of five positive control drugs in hERG external solution (buffer) by LC-MS/MS to support in vitro hERG assay as recommended by ICH S7B.

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Published in 2022 at "Journal of pharmacological and toxicological methods"

DOI: 10.2139/ssrn.4119523

Abstract: ICH S7B recommends screening for hERG channel block using patch clamp recordings to assess a drug's proarrhythmic risk. Block of the hERG channel has been associated with clinical QTC prolongation as well as the rare,… read more here.

Keywords: herg external; ich s7b; external solution;