Identification of Immune Checkpoint Inhibitor-Induced Diabetes.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2024.3104
Abstract: Importance Immune checkpoint inhibitors (ICIs) have revolutionized cancer care; however, accompanying immune-related adverse events (irAEs) confer substantial morbidity and occasional mortality. Life-threatening irAEs may require permanent cessation of ICI, even in patients with positive tumor… read more here.
Keywords: induced diabetes; ici induced; iraes; immune checkpoint ... See more keywords
Gasdermin-E-mediated pyroptosis drives immune checkpoint inhibitor-associated myocarditis via cGAS-STING activation
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DOI: 10.1038/s41467-024-50996-5
Abstract: Immune checkpoint inhibitor (ICI)-induced myocarditis involves intensive immune/inflammation activation; however, its molecular basis is unclear. Here, we show that gasdermin-E (GSDME), a gasdermin family member, drives ICI-induced myocarditis. Pyroptosis mediated by GSDME, but not the… read more here.
Keywords: activation; ici induced; induced myocarditis; myocarditis ... See more keywords
Immune checkpoint inhibitor-induced arthralgia is tightly associated with improved overall survival in cancer patients.
Sign Up to like & getrecommendations! Published in 2022 at "Rheumatology"
DOI: 10.1093/rheumatology/keac519
Abstract: OBJECTIVES With the increased use of immune checkpoint inhibitors (ICIs), arthralgia has been the most commonly reported musculoskeletal immune-related adverse events (irAEs). We aimed to characterise arthralgia and its association with overall survival (OS). METHODS… read more here.
Keywords: immune checkpoint; ici induced; overall survival; induced arthralgia ... See more keywords
6779 The Diversity of Immune Checkpoint Inhibitor Associated Diabetes
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvae163.949
Abstract: Abstract Disclosure: V.A. Mendpara: None. M. Lansang: None. M. Caromori: None. L. Kennedy: None. K. Zhou: None. Immune checkpoint inhibitor (ICI) treatment has become a first-line therapy for a variety of cancers, including use of… read more here.
Keywords: insulin; none; ici induced; inhibitor ... See more keywords
Clinical Features of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Induced by Immune Checkpoint Inhibitor versus Non-Immune Checkpoint Inhibitor Drugs in China: A Cross-Sectional Study and Literature Review
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s491791
Abstract: Purpose Immune checkpoint inhibitors (ICIs) can cause life-threatening Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Large-scale original research on ICI-induced SJS/TEN is limited. This study aimed to explore the unique clinical characteristics and potential… read more here.
Keywords: immune checkpoint; clinical features; ici induced; sjs ten ... See more keywords
Case Report: Challenges in immunotherapy for the elderly: a case of refractory ICI-induced AIHA and thrombocytopenia in advanced gastric cancer
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1679817
Abstract: Immune checkpoint inhibitors (ICIs) have revolutionized cancer immunotherapy. However, immune-related adverse events (irAEs), particularly hematologic toxicities, remain rare but potentially life-threatening complications. Among these, autoimmune hemolytic anemia (AIHA) induced by ICIs is a clinically significant… read more here.
Keywords: cancer; thrombocytopenia; advanced gastric; ici induced ... See more keywords
Immunopathogenesis of Immune Checkpoint Inhibitor Induced Myocarditis: Insights from Experimental Models and Treatment Implications
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11010107
Abstract: Despite the extraordinary success of immune checkpoint inhibitors (ICIs) in cancer treatment, their use is associated with a high incidence of immune-related adverse events (IRAEs), resulting from therapy-related autoimmunity against various target organs. ICI-induced myocarditis… read more here.
Keywords: myocarditis; induced myocarditis; ici induced; immune checkpoint ... See more keywords
CANDIED: A Pan-Canadian Cohort of Immune Checkpoint Inhibitor-Induced Insulin-Dependent Diabetes Mellitus
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers14010089
Abstract: Simple Summary Immune checkpoint inhibitor-induced insulin-dependent diabetes mellitus (ICI-induced IDDM) is an emerging form of autoimmune diabetes. We describe the characteristics of 34 patients who developed ICI-induced IDDM across five Canadian cancer centres. We observed… read more here.
Keywords: response; immune checkpoint; induced iddm; insulin dependent ... See more keywords