Association between EKG Alterations and Clinical Outcomes in Immune Checkpoint Inhibitor-Associated Myocarditis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cardiac Failure"
DOI: 10.1016/j.cardfail.2019.07.207
Abstract: Background Immune checkpoint inhibitors (ICIs) have revolutionized oncologic care. Myocarditis is an uncommon but frequently fatal complication of ICI use. There is need for improved methods of detection and risk stratification of ICI myocarditis. Both… read more here.
Keywords: ici myocarditis; qrs duration; interval; risk ... See more keywords
Myocardial T1 and T2 Mapping by Magnetic Resonance in Patients With Immune Checkpoint Inhibitor-Associated Myocarditis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2021.01.050
Abstract: BACKGROUND Myocarditis is a potentially fatal complication of immune checkpoint inhibitor (ICI) therapy. Data on the utility of cardiovascular magnetic resonance (CMR) T1 and T2 mapping in ICI myocarditis are limited. OBJECTIVES This study sought… read more here.
Keywords: immune checkpoint; patients ici; ici myocarditis; magnetic resonance ... See more keywords
Hormonal therapies up-regulate MANF and overcome female susceptibility to immune checkpoint inhibitor myocarditis
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abo1981
Abstract: Immune checkpoint inhibitors (ICIs) have been increasingly used in combination for cancer treatment but are associated with myocarditis. Here, we report that tumor-bearing mice exhibited response to treatment with combinatorial anti–programmed cell death 1 and… read more here.
Keywords: myocarditis; manf; ici myocarditis; heart ... See more keywords
Sex differences in ICI myocarditis: Hormones to the rescue
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.ade4035
Abstract: Sex hormones may account for sex differences observed in the prevalence and susceptibility of ICI myocarditis (Zhang et al., this issue). Description Sex hormones may account for sex differences observed in the prevalence and susceptibility… read more here.
Keywords: differences ici; ici myocarditis; sex; myocarditis hormones ... See more keywords
Identification of Pathogenic Immune Cell Subsets Associated With Checkpoint Inhibitor–Induced Myocarditis
Sign Up to like & getrecommendations! Published in 2022 at "Circulation"
DOI: 10.1161/circulationaha.121.056730
Abstract: Background: Immune checkpoint inhibitors (ICIs) are monoclonal antibodies used to activate the immune system against tumor cells. Despite therapeutic benefits, ICIs have the potential to cause immune-related adverse events such as myocarditis, a rare but… read more here.
Keywords: myocarditis; cell; ici myocarditis; single cell ... See more keywords