Pepducin ICL1-9-Mediated β2-Adrenergic Receptor-Dependent Cardiomyocyte Contractility Occurs in a Gi Protein/ROCK/PKD-Sensitive Manner
Sign Up to like & getrecommendations! Published in 2022 at "Cardiovascular Drugs and Therapy"
DOI: 10.1007/s10557-021-07299-4
Abstract: β-Adrenergic receptors (βAR) are essential targets for the treatment of heart failure (HF); however, chronic use of βAR agonists as positive inotropes to increase contractility in a Gs protein-dependent manner is associated with increased mortality.… read more here.
Keywords: icl1 mediated; contractility; icl1; cardiomyocyte contractility ... See more keywords
The Role of ICL1 and H8 in Class B1 GPCRs; Implications for Receptor Activation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2021.792912
Abstract: The first intracellular loop (ICL1) of G protein-coupled receptors (GPCRs) has received little attention, although there is evidence that, with the 8th helix (H8), it is involved in early conformational changes following receptor activation as… read more here.
Keywords: class gpcrs; receptor activation; icl1;