Inherently Chiral Macrocycles: Catalytic Asymmetric Synthesis and Properties.
Sign Up to like & getrecommendations! Published in 2025 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.5c00609
Abstract: ConspectusMolecular chirality defines the non-superimposability of three-dimensional molecules onto their mirror images. Due to the often drastically distinct biological effects exhibited by enantiomers, the synthesis of enantiopure small organic molecules remains a topic of persistent… read more here.
Keywords: chemistry; inherently chiral; icms; chiral macrocycles ... See more keywords
Evoking stable and precise tactile sensations via multi-electrode intracortical microstimulation of the somatosensory cortex
Sign Up to like & getrecommendations! Published in 2024 at "Nature Biomedical Engineering"
DOI: 10.1038/s41551-024-01299-z
Abstract: Tactile feedback from brain-controlled bionic hands can be partially restored via intracortical microstimulation (ICMS) of the primary somatosensory cortex. In ICMS, the location of percepts depends on the electrode’s location and the percept intensity depends… read more here.
Keywords: icms; somatosensory cortex; microstimulation; intracortical microstimulation ... See more keywords
The temporal pattern of intracortical microstimulation pulses elicits distinct temporal and spatial recruitment of cortical neuropil and neurons
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neural Engineering"
DOI: 10.1088/1741-2552/abc29c
Abstract: Objective. The temporal spacing or distribution of stimulation pulses in therapeutic neurostimulation waveforms—referred to here as the Temporal Pattern (TP)—has emerged as an important parameter for tuning the response to deep-brain stimulation and intracortical microstimulation… read more here.
Keywords: icms; response; stimulation; temporal pattern ... See more keywords
Visual context affects the perceived timing of tactile sensations elicited through intra-cortical microstimulation: a case study of two participants.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of neurophysiology"
DOI: 10.1152/jn.00518.2024
Abstract: Intra-cortical microstimulation (ICMS) is a technique to provide tactile sensations for a somatosensory brain-machine interface (BMI). A viable BMI must function within the rich, multisensory environment of the real world, but how ICMS is integrated… read more here.
Keywords: icms; cortical microstimulation; tactile sensations; intra cortical ... See more keywords
A single-sample gene-expression classifier for the intrinsic consensus molecular subtypes in colorectal cancer.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2024.42.16_suppl.e15587
Abstract: e15587 Background: An analysis of colorectal cancer epithelial cells showed two intrinsic subtypes called iCMS2 and iCMS3, in addition to the bulk consensus subtypes (CMS1-4). The intrinsic subtypes are prognostically important. We present a robust… read more here.
Keywords: colorectal cancer; ssc; icms; reference ... See more keywords