The Regulation of Initial Coin Offerings in China: Problems, Prognoses and Prospects
Sign Up to like & getrecommendations! Published in 2018 at "European Business Organization Law Review"
DOI: 10.1007/s40804-018-0118-2
Abstract: As a new form of the FinTech industry, initial coin offerings (ICOs) underwent a period of explosive growth in China since the second half of 2016 and were banned in September 2017. However, the outright… read more here.
Keywords: icos; coin offerings; regulation initial; initial coin ... See more keywords
HFA-ICOS cardiovascular toxicity risk score validation in CARDIOTOX registry
Sign Up to like & getrecommendations! Published in 2022 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehac544.2591
Abstract: Cancer therapy-related cardiovascular toxicity (CTox) is a growing medical problem and baseline cardiovascular (CV) risk assessment is recommended in all patients scheduled to receive potentially cardiotoxic cancer therapy. Based on literature review, the Heart Failure… read more here.
Keywords: hfa icos; icos; risk; score ... See more keywords
ICOS+ follicular regulatory T cells are implicated in the pathogenesis of ulcerative colitis
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13568
Abstract: Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) with a rising incidence worldwide. The precise aetiology is unclear, but aberrant regulatory T cell (Treg) responses have been documented in active UC patients. Follicular regulatory… read more here.
Keywords: icos; tfr cells; anti cd3; follicular regulatory ... See more keywords
The role of CD28 in adult T‐cell leukaemia/lymphoma
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Haematology"
DOI: 10.1111/bjh.17214
Abstract: T-cell-specific surface glycoprotein CD28 belongs to the subfamily of costimulatory molecules characterized by an extracellular immunoglobulin variable-like domain. Other members of the subfamily include inducible T-cell costimulator (ICOS), cytotoxic T-lymphocyte-associated antigen 4 (CTLA4), programmed cell… read more here.
Keywords: icos; cell leukaemia; cd28; ctla4 ... See more keywords
International chronic inflammatory demyelinating polyneuropathy outcome study (ICOS): Protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Peripheral Nervous System"
DOI: 10.1111/jns.12296
Abstract: Chronic inflammatory demyelinating polyneuropathy (CIDP) is a heterogeneous immune‐mediated disorder with extensive variation in clinical presentation, electrophysiological phenotype, treatment response and long‐term outcome. This heterogeneity may reflect the existence of distinct subtypes of CIDP with… read more here.
Keywords: icos; outcome; treatment; study ... See more keywords
ICOSL+ plasmacytoid dendritic cells as inducer of graft-versus-host disease, responsive to a dual ICOS/CD28 antagonist
Sign Up to like & getrecommendations! Published in 2020 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aay4799
Abstract: Intestinal CD146+CCR5+ T cells activated by ICOSL+ plasmacytoid DCs during acute GVHD can be inhibited by a dual ICOS/CD28 antagonist. Preventing inside attacks Graft-versus-host disease, where transplanted immune cells attack the recipient, is a major… read more here.
Keywords: icos; versus host; graft versus; host disease ... See more keywords
First-in-Human Phase I/II ICONIC Trial of the ICOS Agonist Vopratelimab Alone and with Nivolumab: ICOS-High CD4 T-Cell Populations and Predictors of Response
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-21-4256
Abstract: Abstract Purpose: The first-in-human phase I/II ICONIC trial evaluated an investigational inducible costimulator (ICOS) agonist, vopratelimab, alone and in combination with nivolumab in patients with advanced solid tumors. Patients and Methods: In phase I, patients… read more here.
Keywords: alone nivolumab; vopratelimab alone; icos; trial ... See more keywords
ICOS immunoPET enables visualization of activated T cells and early diagnosis of murine acute gastrointestinal GvHD
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2022007403
Abstract: Key Points ImmunoPET imaging of ICOS allows for in vivo visualization of T cells in the gastrointestinal tract in a murine model of acute GvHD. ICOS targeting with the immunoPET tracer does not affect GvHD… read more here.
Keywords: visualization; icos immunopet; icos; gvhd icos ... See more keywords
Inducible T-cell co-stimulatory (ICOS) receptor agonist, feladilimab (fela), alone and in combination (combo) with pembrolizumab (P): Results from INDUCE-1 urothelial carcinoma (UC) expansion cohorts (ECs).
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.4519
Abstract: 4519 Background: INDUCE-1 is a first-in-human trial evaluating fela, an IgG4 ICOS agonist non-T-cell depleting mAb, as monotherapy (mono) and in combo with P. ECs include tumor types, such as UC, with high ICOS expression… read more here.
Keywords: combo; fela; activity; disease ... See more keywords
Ikzf2 Regulates the Development of ICOS+ Th Cells to Mediate Immune Response in the Spleen of S. japonicum-Infected C57BL/6 Mice
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.687919
Abstract: Background Th cells (helper T cells) have multiple functions in Schistosoma japonicum (S. japonicum) infection. Inducible co-stimulator (ICOS) is induced and expressed in activated T lymphocytes, which enhances the development of B cells and antibody… read more here.
Keywords: spleen japonicum; icos; icos cells; c57bl mice ... See more keywords
Abnormal Shift in B Memory Cell Profile Is Associated With the Expansion of Circulating T Follicular Helper Cells via ICOS Signaling During Acute HIV-1 Infection
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.837921
Abstract: Interactions between T follicular helper (Tfh) cells and germinal center B cells are essential for the differentiation of B cells and specific antibody responses against HIV-1 infection. However, the extent to which HIV-1 infection affects… read more here.
Keywords: icos; ctfh; infection; memory ... See more keywords