ICP22 of Herpes Simplex Virus 1 Decreases RNA Polymerase Processivity
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DOI: 10.1128/jvi.02191-21
Abstract: The longstanding observation that ICP22 reduces RNA polymerase II (Pol II) serine 2 phosphorylation, which initiates transcriptional elongation, is puzzling because this phosphorylation is essential for viral replication. The current study helps explain this apparent… read more here.
Keywords: polymerase; icp22; rna polymerase; transcriptional elongation ... See more keywords