NLX-112, a highly selective 5-HT1A receptor biased agonist, does not exhibit misuse potential in male rats or macaques
Sign Up to like & getrecommendations! Published in 2022 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2022.109025
Abstract: NLX-112 (a.k.a. F13640 or befiradol) exhibits nanomolar affinity, exceptional selectivity and biased agonism at serotonin 5-HT1A receptors. NLX-112 displays robust analgesic activity in a number of rodent models of pain, and is currently developed as… read more here.
Keywords: misuse potential; ht1a; nlx 112; icss ... See more keywords
Neurosurgical Wrong Surgical Site in Lower-Middle- or Low-Income Countries (LMICs): A Survey Study.
Sign Up to like & getrecommendations! Published in 2021 at "World neurosurgery"
DOI: 10.1016/j.wneu.2021.05.079
Abstract: INTRODUCTION One of the most preventable errors of a surgeon's career is operating on the incorrect surgical site (ICSS). No study in any specialty has ever investigated the incidence of ICSS events in lower-income countries.… read more here.
Keywords: icss; surgical site; survey; income countries ... See more keywords
Unsupervised Change Point Detection and Trend Prediction for Financial Time-Series Using a New CUSUM-Based Approach
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Access"
DOI: 10.1109/access.2022.3162399
Abstract: The aim of this research is to propose a binary segmentation algorithm to detect the change points in financial time-series based on the Iterative Cumulative Sum of Squares (ICSS). The proposed algorithm, entitled KW-ICSS, utilizes… read more here.
Keywords: icss; change; change points; time series ... See more keywords