Paradoxical elevation of plasma dabigatran after reversal with idarucizumab in stroke thrombolysis
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DOI: 10.1007/s00415-018-9011-8
Abstract: Idarucizumab can completely reverse the biological activity of dabigatran within a few minutes [1]. Several reports have documented thrombolytic therapy following antagonism of dabigatran with idarucizumab, and various arrangements have been made in different countries… read more here.
Keywords: plasma dabigatran; dabigatran; concentration; antagonism ... See more keywords
Assessment of patients post reversal with idarucizumab
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DOI: 10.1007/s11239-018-1723-1
Abstract: Idarucizumab, a fully humanized Fab antibody fragment, is indicated for reversal of dabigatran’s anticoagulant activity. Idarucizumab neutralizes the anticoagulant effects of dabigatran by binding to dabigatran and its metabolite. In the full analysis of 503… read more here.
Keywords: reversal; emergent procedure; cohort; dabigatran ... See more keywords
Safe Burr Hole Surgery for Chronic Subdural Hematoma Using Dabigatran with Idarucizumab.
Sign Up to like & getrecommendations! Published in 2018 at "World neurosurgery"
DOI: 10.1016/j.wneu.2017.10.043
Abstract: BACKGROUND Chronic subdural hematoma (CSDH) is a common intracranial hematoma. The number of patients who undergo anticoagulant therapy including a direct oral anticoagulant (DOAC) is expected to increase. Recently, idarucizumab, the antidote for dabigatran, which… read more here.
Keywords: surgery; subdural hematoma; dabigatran; emergency ... See more keywords
Clinical outcomes after reversal of dabigatran in daily practice: real-world use of idarucizumab 2015–2019
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DOI: 10.1093/ehjci/ehaa946.3366
Abstract: Idarucizumab was introduced in Europe in December 2015 as an antidote to dabigatran. Whether reversing the anticoagulant effect of dabigatran actually reduces the risk of bleeding complications and mortality remains sparsely described. No randomized placebo-controlled… read more here.
Keywords: world use; real world; use idarucizumab; idarucizumab ... See more keywords
Idarucizumab for dabigatran overdose in a child
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Haematology"
DOI: 10.1111/bjh.14371
Abstract: We report the first use of idarucizumab in the management of a massive dabigatran overdose in a child. Anticoagulation overdose is a challenging clinical scenario. Dabigatran, an oral direct thrombin inhibitor, is licensed for treatment… read more here.
Keywords: coagulation; dabigatran overdose; dabigatran; history ... See more keywords
Dabigatran reversal with idarucizumab prior to lung transplantation
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DOI: 10.1111/ctr.14142
Abstract: When the transplant candidates are receiving oral anticoagulation therapy before transplantation, it is crucial to have an urgent reversal strategy to prevent hemorrhagic complications perioperatively. The aim of this study was to present the experience… read more here.
Keywords: reversal; prior lung; lung transplantation; transplantation ... See more keywords
The recommended dose of idarucizumab may not always be sufficient for sustained reversal of dabigatran
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DOI: 10.1111/jth.13706
Abstract: Essentials Reversal of anticoagulant effects of dabigatran may occur despite application of idarucizumab. Monitoring of dabigatran level after antidote application is crucial to detect rebound. Repeated doses of idarucizumab may be necessary in cases of… read more here.
Keywords: idarucizumab may; dose idarucizumab; dabigatran; recommended dose ... See more keywords
Idarucizumab does not have procoagulant effects: Assessment of thrombosis biomarkers in healthy volunteers.
Sign Up to like & getrecommendations! Published in 2017 at "Thrombosis and haemostasis"
DOI: 10.1160/th16-05-0385
Abstract: Idarucizumab, a humanised monoclonal antibody fragment, binds dabigatran with high affinity and immediately, completely and sustainably reverses dabigatran-induced changes on blood coagulation. The present analysis focuses on the evaluation of potential procoagulant properties of idarucizumab… read more here.
Keywords: idarucizumab procoagulant; infusion; procoagulant effects; thrombosis ... See more keywords
Antagonizing dabigatran by idarucizumab in cases of ischemic stroke or intracranial hemorrhage in Germany – A national case collection
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DOI: 10.1177/1747493017701944
Abstract: Background Idarucizumab is a monoclonal antibody fragment with high affinity for dabigatran that reverses its anticoagulant effects within minutes. It may exhibit the potential for patients under dabigatran therapy suffering ischemic stroke to regain eligibility… read more here.
Keywords: ischemic stroke; intracranial hemorrhage; hemorrhage; dabigatran ... See more keywords
Stroke reperfusion therapy following dabigatran reversal with idarucizumab in a national cohort
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DOI: 10.1212/wnl.0000000000009155
Abstract: Objective To assess the frequency and utilization trends of dabigatran reversal with idarucizumab and compare associated complications, outcomes, and door-to-needle times to those of patients not exposed to idarucizumab in a nationwide cohort of thrombolyzed… read more here.
Keywords: dabigatran reversal; reversal idarucizumab; idarucizumab; thrombolyzed patients ... See more keywords
A dabigatran-antidótum, az intravénás idarucizumab első hazai alkalmazása
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DOI: 10.1556/650.2017.30684
Abstract: Absztrakt: Az uj tipusu, direkt oralis antikoagulansok kozul jelenleg egyedul a direkt trombingatlo dabigatran rendelkezik hatekony antidotummal. Az idarucizumab egy humanizalt, monoklonalis dabigatrant megkotő antitestfragmentum, amely a gyogyszer szelektiv veralvadasgatlo hatasat azonnal, tartosan, biztonsagosan felfuggeszti.… read more here.
Keywords: dabigatran antid; idarucizumab els; dabigatran; antid tum ... See more keywords