A population-based study identifies an association of THBS2 with intervertebral disc degeneration.
Sign Up to like & getrecommendations! Published in 2019 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2019.06.001
Abstract: OBJECTIVE To clarify the genetic mechanisms underlying intervertebral disc degeneration (IDD), we examined the associations between single-nucleotide polymorphisms (SNPs) and IDD in a general population in Japan. METHODS This was a cross-sectional study. In 1,605… read more here.
Keywords: age; disc degeneration; idd; intervertebral disc ... See more keywords
FokI as a genetic factor of intervertebral disc degeneration: A PRISMA-compliant systematic review of overlapping meta-analyses
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2018.09.028
Abstract: The association of FokI (rs2228570), a polymorphism of the vitamin D receptor gene, with intervertebral disc degeneration (IDD) has been investigated in a multitude of studies. However, conflicting results of these studies led to emergence… read more here.
Keywords: meta analyses; meta; association foki; idd ... See more keywords
Characterization of An Extensive Interface on Vitronectin for Binding to PAI-1: Adoption of Structure in an Intrinsically Disordered Region.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00605
Abstract: Small-angle neutron scattering (SANS) measurements were pursued to study human vitronectin, a protein found in tissues and the circulation that regulates cell adhesion/migration and proteolytic cascades that govern hemostasis and pericellular proteolysis. Many of these… read more here.
Keywords: vitronectin; pai; binding pai; idd ... See more keywords
Research progress in decellularized extracellular matrix hydrogels for intervertebral disc degeneration.
Sign Up to like & getrecommendations! Published in 2023 at "Biomaterials science"
DOI: 10.1039/d2bm01862d
Abstract: As one of the most common clinical disorders, low back pain (LBP) influences patient quality of life and causes substantial social and economic burdens. Many factors can result in LBP, the most common of which… read more here.
Keywords: disc degeneration; intervertebral disc; idd; research ... See more keywords
MicroRNA-129-5p affects immune privilege and apoptosis of nucleus pulposus cells via regulating FADD in intervertebral disc degeneration
Sign Up to like & getrecommendations! Published in 2020 at "Cell Cycle"
DOI: 10.1080/15384101.2020.1732515
Abstract: ABSTRACT Literatures indicate that microRNA-129-5p (miR-129-5p) or Fas-associated death domain (FADD) is related to intervertebral disc degeneration (IDD), but the effect of miR-129-5p/FADD axis on IDD is not studied. The study aimed to investigate whether… read more here.
Keywords: apoptosis; mir 129; idd; nucleus pulposus ... See more keywords
The Role of Type I Diabetes in Intervertebral Disc Degeneration.
Sign Up to like & getrecommendations! Published in 2019 at "Spine"
DOI: 10.1097/brs.0000000000003054
Abstract: STUDY DESIGN An experimental laboratory study. OBJECTIVE To investigate the pathogenesis of intervertebral disc degeneration (IDD) in a murine model of type 1 diabetes mellitus (DM), namely non-obese diabetic (NOD) mouse. SUMMARY OF BACKGROUND DATA… read more here.
Keywords: idd; type diabetes; intervertebral disc; disc degeneration ... See more keywords
Circular RNAs in nucleus pulposus cell function and intervertebral disc degeneration
Sign Up to like & getrecommendations! Published in 2019 at "Cell Proliferation"
DOI: 10.1111/cpr.12704
Abstract: Intervertebral disc degeneration (IDD) is a common cause of low back pain, which inflicts more global disability than any other condition. Although IDD was deemed to be a natural process that comes with ageing, a… read more here.
Keywords: circular rnas; idd; intervertebral disc; nucleus pulposus ... See more keywords
The Mechanisms and Functions of GDF‐5 in Intervertebral Disc Degeneration
Sign Up to like & getrecommendations! Published in 2021 at "Orthopaedic Surgery"
DOI: 10.1111/os.12942
Abstract: Intervertebral disc degeneration (IDD) is widely recognized as the main cause of low back pain, which leads to disability in aging populations and induces great losses both socially and economically worldwide. Unfortunately, current treatments for… read more here.
Keywords: idd; intervertebral disc; growth; disc degeneration ... See more keywords
The Mechanism and Function of miRNA in Intervertebral Disc Degeneration
Sign Up to like & getrecommendations! Published in 2022 at "Orthopaedic Surgery"
DOI: 10.1111/os.13204
Abstract: Intervertebral disc degeneration (IDD) disease has been considered as the main cause of low back pain (LBP), which is a very common symptom and the leading cause of disability worldwide today. The pathological mechanism of… read more here.
Keywords: degeneration; mechanism; disc degeneration; intervertebral disc ... See more keywords
The Effect of Gut Microbiota on the Progression of Intervertebral Disc Degeneration
Sign Up to like & getrecommendations! Published in 2023 at "Orthopaedic Surgery"
DOI: 10.1111/os.13626
Abstract: Intervertebral disc degeneration (IDD) is the main cause of back pain, and its treatment is a serious socio‐economic burden. The safety and treatment of fecal microbiota transplantation (FMT) has been established. However, the relationship between… read more here.
Keywords: idd; microbiota; disc degeneration; intervertebral disc ... See more keywords
Oxidative Stress in Intervertebral Disc Degeneration: New Insights from Bioinformatic Strategies
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/2239770
Abstract: Oxidative stress has been proved to play important roles in the development of intervertebral disc degeneration (IDD); however, the underlying mechanism remains obscure to date. The aim of this study was to elucidate the vital… read more here.
Keywords: stress; oxidative stress; disc degeneration; intervertebral disc ... See more keywords