Protective Effects of Idebenone against Sepsis Induced Acute Lung Damage
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Investigative Surgery"
DOI: 10.1080/08941939.2021.1898063
Abstract: Abstract Background/Aims Sepsis is an uncontrolled systemic infection, withcomplex pathophysiology that may result in acute lung organ damage and cause multiple organ failure. Although much research has been conducted to illuminate sepsis’s complex pathophysiology, sepsis… read more here.
Keywords: lung; damage; sepsis; sepsis induced ... See more keywords
Comment on ‘Long‐term prognosis with or without nucleot(s)ide analogue therapy in hepatitis B virus‐related decompensated cirrhosis’
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Viral Hepatitis"
DOI: 10.1111/jvh.13515
Abstract: We read with interest the study by Kumada et al entitled "Long-term prognosis with or without nucleot(s)ide analogue therapy in hepatitis B virus-related decompensated cirrhosis" recently published in the Journal of Viral Hepatitis1 . The… read more here.
Keywords: hepatitis; long term; ide; related decompensated ... See more keywords
Proteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent manner
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0174254
Abstract: There is a significantly higher risk for type II diabetes in HIV-1 carriers, albeit the molecular mechanism for this HIV-related pathology remains enigmatic. The 52 amino acid HIV-1 p6 Gag protein is synthesized as the… read more here.
Keywords: insulin; gag; hiv; virus replication ... See more keywords
Antibody-Mediated Inhibition of Insulin-Degrading Enzyme Improves Insulin Activity in a Diabetic Mouse Model
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.835774
Abstract: Diabetes is a metabolic disease that may lead to different life-threatening complications. While insulin constitutes a beneficial treatment, its use may be limited due to increased degradation and an increase in side effects such as… read more here.
Keywords: insulin activity; mouse; ide; antibody ... See more keywords
Insights into Non-Proteolytic Inhibitory Mechanisms of Polymorphic Early-Stage Amyloid β Oligomers by Insulin Degrading Enzyme
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12121886
Abstract: Insulin degrading enzyme (IDE) has been detected in the cerebrospinal fluid media and plays a role in encapsulating and degrading the amyloid β (Aβ) monomer, thus regulating the levels of Aβ monomers. The current work… read more here.
Keywords: early stage; insulin degrading; ide; stage ... See more keywords
Insulin-Degrading Enzyme Interacts with Mitochondrial Ribosomes and Respiratory Chain Proteins
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13060890
Abstract: Insulin-degrading enzyme (IDE) is a highly conserved metalloprotease that is mainly localized in the cytosol. Although IDE can degrade insulin and some other low molecular weight substrates efficiently, its ubiquitous expression suggests additional functions supported… read more here.
Keywords: interacts mitochondrial; enzyme interacts; insulin degrading; ide ... See more keywords
Rapid Inkjet-Printed Miniaturized Interdigitated Electrodes for Electrochemical Sensing of Nitrite and Taste Stimuli
Sign Up to like & getrecommendations! Published in 2021 at "Micromachines"
DOI: 10.3390/mi12091037
Abstract: This paper reports on single step and rapid fabrication of interdigitated electrodes (IDEs) using an inkjet printing-based approach. A commercial inkjet-printed circuit board (PCB) printer was used to fabricate the IDEs on a glass substrate.… read more here.
Keywords: taste; inkjet printed; ide; sensor ... See more keywords
Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.33572
Abstract: Insulin degrading enzyme (IDE) plays key roles in degrading peptides vital in type two diabetes, Alzheimer's, inflammation, and other human diseases. However, the process through which IDE recognizes peptides that tend to form amyloid fibrils… read more here.
Keywords: insulin; cryoem; degrading enzyme; insulin degrading ... See more keywords