Molecular Determinants of Substrate Specificity in Human Insulin-Degrading Enzyme.
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DOI: 10.1021/acs.biochem.8b00474
Abstract: Insulin-degrading enzyme (IDE) is a 110 kDa chambered zinc metalloendopeptidase that degrades insulin, amyloid β, and other intermediate-sized aggregation prone peptides that adopt β-structures. Structural studies of IDE in complex with multiple physiological substrates have… read more here.
Keywords: insulin; degrading enzyme; insulin degrading; active site ... See more keywords