Nucleos(t)ide analogues potentially activate T lymphocytes through inducing interferon expression in hepatic cells and patients with chronic hepatitis B
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DOI: 10.1038/s41598-024-76270-8
Abstract: Chronic hepatitis B (CHB) leads to liver inflammation and dysfunction, resulting in liver fibrosis and cancer. Nucleos(t)ide analogues (NAs), inhibitors of hepatitis B virus (HBV), specifically suppress HBV replication. We proposed that immune modulation benefits… read more here.
Keywords: hbv; ide analogues; ast alt; nucleos ide ... See more keywords
Extrahepatic carcinogenicity of oral nucleos(t)ide analogues in chronic hepatitis B carriers: A 35,000‐Korean outcome study
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DOI: 10.1111/jvh.13721
Abstract: Evidence on the carcinogenicity of oral nucleos(t)ide analogues (NAs) is inconclusive and lacks data on the effects by chemical structure of the NAs in patients with chronic hepatitis B (CHB). We aimed to provide definitive… read more here.
Keywords: nucleos ide; carcinogenicity oral; ide analogues; chronic hepatitis ... See more keywords
Validation Study of Scores Predicting Hepatocellular Carcinoma Risk in Chronic Hepatitis B Patients Treated With Nucleos(t)ide Analogues
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DOI: 10.1111/jvh.70021
Abstract: Chronic hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma (HCC) worldwide. Nucleos(t)ide analogues (NAs) are widely used in chronically HBV‐infected patients, but the risk of HCC still remains in NA‐treated patients.… read more here.
Keywords: risk; score; ide analogues; patients treated ... See more keywords
HBV Suppression by Nucleos(t)ide Analogues Reduces PD‐1 Expression on Liver‐Resident T Cells
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DOI: 10.1111/liv.70338
Abstract: PD‐1‐expressing T cells within the HBV‐infected liver constitute a target of novel immunotherapeutics. Our aim was to investigate the impact of viral suppression on PD‐1 expression on intrahepatic versus circulating lymphocyte populations from chronic hepatitis… read more here.
Keywords: hbv suppression; suppression nucleos; ide analogues; nucleos ide ... See more keywords
Safety Considerations for Withdrawal of Nucleos(t)ide Analogues in Patients with Chronic Hepatitis B: First, Do No Harm.
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DOI: 10.3350/cmh.2022.0420
Abstract: Nucleos(t)ide analogues (NA) are widely used to treat hepatitis B virus (HBV) infection, but they cannot eradicate the virus and treatment duration can be lifelong if the endpoint is set at seroclearance of the hepatitis… read more here.
Keywords: safety; nucleos ide; ide analogues; hepatitis ... See more keywords