Shc inhibitor idebenone ameliorates liver injury and fibrosis in dietary NASH in mice
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22876
Abstract: Shc expression rises in human nonalcoholic steatohepatitis (NASH) livers, and Shc‐deficient mice are protected from NASH—thus Shc inhibition could be a novel therapeutic strategy for NASH. Idebenone was recently identified as the first small‐molecule Shc… read more here.
Keywords: fibrosis; shc expression; idebenone ameliorates; shc inhibitor ... See more keywords
Treatment effect of idebenone on inspiratory function in patients with Duchenne muscular dystrophy
Sign Up to like & getrecommendations! Published in 2017 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.23547
Abstract: Assessment of dynamic inspiratory function may provide valuable information about the degree and progression of pulmonary involvement in patients with Duchenne muscular dystrophy (DMD). The aims of this study were to characterize inspiratory function and… read more here.
Keywords: inspiratory function; idebenone; function; max fvc ... See more keywords
Characteristics of Japanese patients with Leber’s hereditary optic neuropathy and idebenone trial: a prospective, interventional, non-comparative study
Sign Up to like & getrecommendations! Published in 2020 at "Japanese Journal of Ophthalmology"
DOI: 10.1007/s10384-020-00789-2
Abstract: Purpose Leber’s hereditary optic neuropathy (LHON) is a mitochondrial neuropathy that causes acute vision loss. Idebenone, a short-chain ubiquinone analog that preserves mitochondrial function is thought to suppress disease progression in early-onset LHON patients. We… read more here.
Keywords: study; hereditary optic; idebenone; leber hereditary ... See more keywords
Idebenone attenuates cerebral inflammatory injury in ischemia and reperfusion via dampening NLRP3 inflammasome activity.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.04.013
Abstract: BACKGROUND Idebenone is a well-appreciated mitochondrial protectant while the mechanisms underlying the neuroprotection in cerebral ischemia and reperfusion (I/R) remain elusive. It has been manifested NLRP3 inflammasom activation contributed to I/R induced damage. It raises… read more here.
Keywords: ischemia reperfusion; idebenone; activation; inflammatory injury ... See more keywords
Idebenone: When an antioxidant is not an antioxidant
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101812
Abstract: Idebenone is a well described drug that was initially developed against dementia. The current literature widely portrays this molecule as a potent antioxidant and CoQ10 analogue. While numerous papers seem to support this view, a… read more here.
Keywords: idebenone antioxidant; antioxidant antioxidant; idebenone; biology ... See more keywords
A carbohydrate polymer is a critical variable in the formulation of drug nanocrystals: a case study of idebenone
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2019.1682546
Abstract: ABSTRACT Objective: Stabilizers, especially carbohydrate polymers, have been shown to be necessary for the stabilization of drug nanocrystals. However, the impacts of select stabilizers on the in vitro and in vivo efficacy of therapeutics have… read more here.
Keywords: formulation drug; idbnc; study; drug ... See more keywords
Clinical outcomes of treatment with idebenone in Leber's hereditary optic neuropathy in the Netherlands: A national cohort study
Sign Up to like & getrecommendations! Published in 2022 at "Acta Ophthalmologica"
DOI: 10.1111/aos.15153
Abstract: The purpose of the study was to present results from a national Dutch cohort of patients with Leber's Hereditary Optic Neuropathy (LHON) treated with idebenone. read more here.
Keywords: optic neuropathy; idebenone; hereditary optic; cohort ... See more keywords
Tcap Deficiency in Zebrafish Leads to ROS Production and Mitophagy, and Idebenone Improves its Phenotypes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.836464
Abstract: Limb-girdle muscular dystrophy 2G (LGMD2G) is a subtype of limb-girdle muscular dystrophy. However, the disease’s mechanisms are still not fully understood, and no established therapeutic targets have been found. Using a morpholino-based knockdown approach, we… read more here.
Keywords: tcap deficiency; lgmd2g zebrafish; idebenone; ros level ... See more keywords
Idebenone Regulates Aβ and LPS-Induced Neurogliosis and Cognitive Function Through Inhibition of NLRP3 Inflammasome/IL-1β Axis Activation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.749336
Abstract: Idebenone is an analogue of coenzyme Q10, an electron donor in the mitochondrial electron transport chain, and thus may function as an antioxidant to facilitate mitochondrial function. However, whether idebenone modulates LPS- and Aβ-mediated neuroinflammatory… read more here.
Keywords: nlrp3 inflammasome; activation; function; lps induced ... See more keywords
Idebenone Alleviates Neuroinflammation and Modulates Microglial Polarization in LPS-Stimulated BV2 Cells and MPTP-Induced Parkinson’s Disease Mice
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2018.00529
Abstract: Background: Idebenone is an antioxidant and a coenzyme Q10 analog that has been used to treat neurodegeneration disease. Some studies show idebenone exerts anti-inflammatory effects. However, whether idebenone can be used to reduce the neuroinflammation… read more here.
Keywords: lps stimulated; mptp induced; idebenone; parkinson disease ... See more keywords
Improving Sperm Oxidative Stress and Embryo Quality in Advanced Paternal Age Using Idebenone In Vitro—A Proof-of-Concept Study
Sign Up to like & getrecommendations! Published in 2021 at "Antioxidants"
DOI: 10.3390/antiox10071079
Abstract: Advanced paternal age is associated with increased sperm reactive oxygen species (ROS) and decreased fertilization and pregnancy rates. Sperm washing during infertility treatment provides an opportunity to reduce high sperm ROS concentrations associated with advanced… read more here.
Keywords: paternal age; ros concentrations; advanced paternal; embryo ... See more keywords