Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ.
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DOI: 10.1021/acs.jmedchem.2c00998
Abstract: DNA polymerase theta (Polθ) is an attractive synthetic lethal target for drug discovery, predicted to be efficacious against breast and ovarian cancers harboring BRCA-mutant alleles. Here, we describe our hit-to-lead efforts in search of a… read more here.
Keywords: identification 6685; dna polymerase; pol; orally bioavailable ... See more keywords