In silico identification of a β2-adrenoceptor allosteric site that selectively augments canonical β2AR-Gs signaling and function
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DOI: 10.1073/pnas.2214024119
Abstract: Significance β2ARs are the primary targets for relieving bronchoconstriction in airway diseases such as asthma and COPD. Activation of airway smooth muscle (ASM) β2ARs promotes therapeutic effects (via β2AR-Gs pathway) that are constrained by β2AR… read more here.
Keywords: function; allosteric site; identification adrenoceptor; silico identification ... See more keywords