Identification of Allosteric Effects in Proteins by Elastic Network Models.
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DOI: 10.1007/978-1-0716-1154-8_3
Abstract: Allostery is a fundamental regulatory mechanism in the majority of biological processes of molecular machines. Allostery is well-known as a dynamic-driven process, and thus, the molecular mechanism of allosteric signal transmission needs to be established.… read more here.
Keywords: allosteric effects; network; network models; model ... See more keywords
Advances in the Computational Identification of Allosteric Sites and Pathways in Proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-8719-7_7
Abstract: With the increasing difficulty to develop new drugs and the emergence of resistance to traditional orthosteric-site inhibitors, the search for alternatives is finally approaching the focus on allosteric sites. Allosteric sites offer opportunities to regulate many pharmacologically targeted… read more here.
Keywords: allosteric sites; identification allosteric; sites pathways; computational identification ... See more keywords
Identification of allosteric disulfides from labile bonds in X-ray structures
Sign Up to like & getrecommendations! Published in 2018 at "Royal Society Open Science"
DOI: 10.1098/rsos.171058
Abstract: Protein disulfide bonds link pairs of cysteine sulfur atoms and are either structural or functional motifs. The allosteric disulfides control the function of the protein in which they reside when cleaved or formed. Here, we… read more here.
Keywords: disulfide bonds; bond; disulfides labile; ray structures ... See more keywords