Identification of a broadly conserved family of enzymes that hydrolyze (p)ppApp.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2213771120
Abstract: Bacteria produce a variety of nucleotide second messengers to adapt to their surroundings. Although chemically similar, the nucleotides guanosine penta- and tetraphosphate [(p)ppGpp] and adenosine penta- and tetraphosphate [(p)ppApp] have distinct functions in bacteria. (p)ppGpp… read more here.
Keywords: hydrolyze ppapp; family; identification broadly; ppapp hydrolases ... See more keywords
Identification of Broadly Applicable Adeno-Associated Virus Vectors by Systematic Comparison of Commonly Used Capsid Variants In Vitro
Sign Up to like & getrecommendations! Published in 2022 at "Human Gene Therapy"
DOI: 10.1089/hum.2022.109
Abstract: Adeno-associated viruses (AAVs) represent highly attractive gene therapy vectors and potent research tools for the modulation of gene expression in animal models or difficult-to-transfect cell cultures. Engineered variants, comprising chimeric, mutated, or peptide-inserted capsids, have… read more here.
Keywords: cell; adeno associated; identification broadly; broadly applicable ... See more keywords