Identification of cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses
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DOI: 10.1073/pnas.2206104119
Abstract: Significance Bunyaviruses, like influenza viruses, possess a cap-dependent endonuclease (CEN) that mediates the critical cap-snatching step of viral RNA transcription. We identified the antibunyavirus compounds among influenza CEN inhibitors and identified specific structures involved in… read more here.
Keywords: identification cap; cap dependent; cap; dependent endonuclease ... See more keywords