Identification of Compounds That Interfere with High‐Throughput Screening Assay Technologies
Sign Up to like & getrecommendations! Published in 2019 at "Chemmedchem"
DOI: 10.1002/cmdc.201900395
Abstract: A significant challenge in high‐throughput screening (HTS) campaigns is the identification of assay technology interference compounds. A Compound Interfering with an Assay Technology (CIAT) gives false readouts in many assays. CIATs are often considered viable… read more here.
Keywords: identification compounds; high throughput; compounds interfere; assay technologies ... See more keywords
Identification of Compounds Contributing to Trigeminal Pungency of Baijiu by Sensory Evaluation, Quantitative Measurements, Correlation Analysis, and Sensory Verification Testing.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c06875
Abstract: Pungency is one of the most important mouthfeel characteristics that is primarily related to the sensory quality of distilled spirits. However, the chemical basis of pungency is still unclear. A set of Baijiu samples with… read more here.
Keywords: analysis; identification compounds; pungency; pungency baijiu ... See more keywords
Identification of Compounds Targeting HuD: Another Brick in the Wall of Neurodegenerative Disease Treatment.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00191
Abstract: ELAV-like (ELAVL) RNA-binding proteins play a pivotal role in post-transcriptional processes, and their dysregulation is involved in several pathologies. This work was focused on HuD (ELAVL4), which is specifically expressed in nervous tissues, and involved… read more here.
Keywords: hud; identification compounds; treatment; targeting hud ... See more keywords
Identification of 4 compounds from the Pharmakon library with antifungal activity against Candida auris and species of Cryptococcus.
Sign Up to like & getrecommendations! Published in 2022 at "Medical mycology"
DOI: 10.1093/mmy/myac033
Abstract: There is an urgent need to develop novel antifungals. In this study, we screened 1600 compounds for antifungal activity against Cryptococcus neoformans and Candida auris. We evaluated 4 promising compounds against 24 additional isolates of… read more here.
Keywords: pharmakon library; antifungal activity; candida auris; identification compounds ... See more keywords