Identification of a conserved and acute neurodegeneration‐specific microglial transcriptome in the zebrafish
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23083
Abstract: Microglia are brain resident macrophages important for brain development, connectivity, homeostasis and disease. However, it is still largely unclear how microglia functions and their identity are regulated at the molecular level. Although recent transcriptomic studies… read more here.
Keywords: acute neurodegeneration; conserved acute; neurodegeneration specific; microglia ... See more keywords
Identification of a conserved N‐terminal domain in the first module of ACV synthetases
Sign Up to like & getrecommendations! Published in 2021 at "MicrobiologyOpen"
DOI: 10.1002/mbo3.1145
Abstract: The l‐δ‐(α‐aminoadipoyl)‐l‐cysteinyl‐d‐valine synthetase (ACVS) is a trimodular nonribosomal peptide synthetase (NRPS) that provides the peptide precursor for the synthesis of β‐lactams. The enzyme has been extensively characterized in terms of tripeptide formation and substrate specificity.… read more here.
Keywords: terminal domain; conserved terminal; first module; domain first ... See more keywords
Novel approaches on identification of conserved miRNAs for broad-spectrum Potyvirus control measures.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06271-7
Abstract: Potyviridae comprises more than 200 ssRNA viruses, many of which have a broad host range and geographical distributions. Potyvirids (members of Potyviridae) infect several economically important plants such as saffron, cardamom, cucumber, pepper, potato, tomato,… read more here.
Keywords: approaches identification; conserved mirnas; novel approaches; identification conserved ... See more keywords
Identification of Conserved Proteomic Networks in Neurodegenerative Dementia
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107807
Abstract: SUMMARY Data-driven analyses are increasingly valued in modern medicine. We integrate quantitative proteomics and transcriptomics from over 1,000 post-mortem brains from six cohorts representing Alzheimer’s disease (AD), asymptomatic AD, progressive supranuclear palsy (PSP), and control… read more here.
Keywords: medicine; proteomic networks; neurodegenerative dementia; conserved proteomic ... See more keywords
Identification of conserved evolutionary trajectories in tumors.
Sign Up to like & getrecommendations! Published in 2020 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btaa453
Abstract: MOTIVATION As multi-region, time-series and single-cell sequencing data become more widely available; it is becoming clear that certain tumors share evolutionary characteristics with others. In the last few years, several computational methods have been developed… read more here.
Keywords: conserved evolutionary; evolutionary trajectories; conett; trajectories tumors ... See more keywords
In silico identification of conserved miRNAs and their selective target gene prediction in indicine (Bos indicus) cattle
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0206154
Abstract: The modern cattle was domesticated from aurochs, sharing its physiological traits into two subspecies Bos taurus and Bos indicus. MicroRNAs (miRNAs) are a class of non-coding short RNAs of ~22nt which have a key role… read more here.
Keywords: bos indicus; mirna; silico identification; target ... See more keywords
Identification of a Conserved, Linear Epitope on VP3 of Enterovirus A Species Recognized by a Broad-Spectrum Monoclonal Antibody
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15041028
Abstract: Outbreaks of hand, foot and mouth disease (HFMD) have occurred frequently in the Asian-Pacific region over the last two decades, caused mainly by the serotypes in Enterovirus A species. High-quality monoclonal antibodies (mAbs) are needed… read more here.
Keywords: enterovirus; identification conserved; linear epitope; enterovirus species ... See more keywords
Identification of a conserved S2 epitope present on spike proteins from all highly pathogenic coronaviruses
Sign Up to like & getrecommendations! Published in 2023 at "eLife"
DOI: 10.7554/elife.83710
Abstract: To address the ongoing SARS-CoV-2 pandemic and prepare for future coronavirus outbreaks, understanding the protective potential of epitopes conserved across SARS-CoV-2 variants and coronavirus lineages is essential. We describe a highly conserved, conformational S2 domain… read more here.
Keywords: conserved epitope; identification conserved; present spike; sars cov ... See more keywords