Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering.
Sign Up to like & getrecommendations! Published in 2020 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2020.04.004
Abstract: The BCL-2 family is composed of anti- and pro-apoptotic members that respectively protect or disrupt mitochondrial integrity. Anti-apoptotic overexpression can promote oncogenesis by trapping the BCL-2 homology 3 (BH3) "killer domains" of pro-apoptotic proteins in… read more here.
Keywords: disulfide tethering; covalent molecular; identification covalent; bfl ... See more keywords
Identification of covalent inhibitors that disrupt M. tuberculosis growth by targeting multiple serine hydrolases involved in lipid metabolism.
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DOI: 10.1016/j.chembiol.2021.08.013
Abstract: The increasing incidence of antibiotic-resistant Mycobacterium tuberculosis infections is a global health threat necessitating the development of new antibiotics. Serine hydrolases (SHs) are a promising class of targets because of their importance for the synthesis… read more here.
Keywords: covalent inhibitors; identification covalent; serine hydrolases; tuberculosis growth ... See more keywords
Identification of a covalent binder to the oncoprotein gankyrin using a NIR-Based OBOC screening method
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DOI: 10.1039/d0ra10976b
Abstract: Despite huge advancements in the process of synthesizing small molecules as part of one-bead-one-compound (OBOC) libraries, progress lags in the ability to rank potential hits from a primary library screen. read more here.
Keywords: covalent binder; gankyrin using; identification covalent; binder oncoprotein ... See more keywords