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   Articles with "identification functional" as a keyword



Identification and functional comparison of novel alternatively spliced isoforms of human YAP.

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recommendations! Published in 2023 at "FEBS open bio"

DOI: 10.1002/2211-5463.13618

Abstract: As a key effector of the Hippo pathway, yes‐associated protein (YAP) is a major regulator of cell proliferation and apoptosis. In this study, 23 hYAP isoforms were identified in HEK293 cells, with 14 isoforms being… read more here.

Keywords: identification functional; alternatively spliced; novel alternatively; hyap isoforms ... See more keywords

Identification and Functional Analysis of Chitin Synthase A in Oriental Armyworm, Mythimna separata

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recommendations! Published in 2017 at "PROTEOMICS"

DOI: 10.1002/pmic.201700165

Abstract: Chitin synthases are very important enzymes for chitin synthesis in various species, which makes them a specific target of insecticides. In the present study, the function of the chitin synthase A (CHSA) gene isolated from… read more here.

Keywords: chitin synthase; analysis chitin; chitin; identification functional ... See more keywords
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An identification and functional evaluation of a novel CYP2C9 variant CYP2C9*62.

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recommendations! Published in 2020 at "Chemico-biological interactions"

DOI: 10.1016/j.cbi.2020.109168

Abstract: Warfarin is the most commonly used anticoagulant in the clinical treatment of thromboembolic diseases. The dose of warfarin varies significantly within populations, and the dose is closely related to the genetic polymorphisms of the CYP2C9… read more here.

Keywords: functional evaluation; evaluation novel; identification functional; cyp2c9 ... See more keywords

Identification of a functional FADS1 3'UTR variant associated with erythrocyte n-6 polyunsaturated fatty acids levels.

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recommendations! Published in 2018 at "Journal of clinical lipidology"

DOI: 10.1016/j.jacl.2018.07.012

Abstract: BACKGROUND Blood polyunsaturated fatty acid (PUFA) levels are determined by diet and by endogenous synthesis via Δ5- and Δ6-desaturases (encoded by the FADS1 and FADS2 genes, respectively). Genome-wide association studies have reported associations between FADS1-FADS2… read more here.

Keywords: polyunsaturated fatty; fads1 fads2; variant; fads1 utr ... See more keywords

Identification and functional analysis of ferritin 2 from the Taiga tick Ixodes persulcatus Schulze.

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recommendations! Published in 2020 at "Ticks and tick-borne diseases"

DOI: 10.1016/j.ttbdis.2020.101547

Abstract: Ferritin 2 (FER2) is an iron storage protein, which has been shown to be critical for iron homeostasis during blood feeding and reproduction in ticks and is therefore suitable as a component for anti-tick vaccines.… read more here.

Keywords: fer2; tick; ixodes persulcatus; analysis ... See more keywords

Identification and Functional Validation of the Role of Solute Carriers in Shaping Xenobiotic Tolerance in Polyphagous Pests of Spodoptera litura.

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recommendations! Published in 2025 at "Journal of agricultural and food chemistry"

DOI: 10.1021/acs.jafc.5c12376

Abstract: As a global pest, Spodoptera litura causes significant economic losses annually, making it imperative to investigate its metabolic detoxification mechanisms. The solute carrier (SLC) gene constitutes a superfamily of genes that can directly or indirectly… read more here.

Keywords: xenobiotic tolerance; identification functional; tolerance; spodoptera litura ... See more keywords

Identification and Functional Characterization of Fungal Chalcone Synthase and Chalcone Isomerase

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recommendations! Published in 2023 at "Journal of Natural Products"

DOI: 10.1021/acs.jnatprod.2c01027

Abstract: By mining fungal genomic information, a noncanonical iterative type I PKS fused with an N-terminal adenylation–thiolation didomain, which catalyzes the formation of naringenin chalcone, was found. Structural prediction and molecular docking analysis indicated that a… read more here.

Keywords: chalcone synthase; functional characterization; identification functional; fungal chalcone ... See more keywords

Identification of functional non-coding variants associated with orofacial cleft

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-61734-w

Abstract: Oral facial cleft (OFC) comprises cleft lip with or without cleft palate (CL/P) or cleft palate only. Genome wide association studies (GWAS) of isolated OFC have identified common single nucleotide polymorphisms (SNPs) in many genomic… read more here.

Keywords: non coding; orofacial cleft; identification functional; variants associated ... See more keywords

Identification and functional validation of super-enhancers in Arabidopsis thaliana

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2215328119

Abstract: Significance Super-enhancers (SEs) are exceptionally large enhancers and play prominent roles in cell type identity and function in mammalian species. We identified a set of 749 putative SEs in the model plant Arabidopsis thaliana. We… read more here.

Keywords: identification functional; super enhancers; validation super; functional validation ... See more keywords

Identification and functional validation of kynureninases from oral bacteria

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recommendations! Published in 2025 at "Journal of Oral Microbiology"

DOI: 10.1080/20002297.2025.2561213

Abstract: Abstract Background The kynurenine (KYN) pathway produces key metabolites for immunoregulation and neuromodulation in humans, but its presence and activity in the oral microbiome are unclear. This study investigates the functionality of the key kynureninase… read more here.

Keywords: functional validation; identification functional; oral bacteria; validation kynureninases ... See more keywords

ProtPhage: a deep learning framework for phage viral protein identification and functional annotation

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recommendations! Published in 2025 at "Briefings in Bioinformatics"

DOI: 10.1093/bib/bbaf285

Abstract: Abstract Phages, viruses that infect bacteria, offer a promising strategy against antibiotic-resistant pathogens. Phage viral proteins (PVPs) are essential for phage–host interactions, yet their identification and functional annotation remain challenging due to high sequence diversity,… read more here.

Keywords: deep learning; functional annotation; phage; identification functional ... See more keywords