Identification and functional comparison of novel alternatively spliced isoforms of human YAP.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS open bio"
DOI: 10.1002/2211-5463.13618
Abstract: As a key effector of the Hippo pathway, yes‐associated protein (YAP) is a major regulator of cell proliferation and apoptosis. In this study, 23 hYAP isoforms were identified in HEK293 cells, with 14 isoforms being… read more here.
Keywords: identification functional; alternatively spliced; novel alternatively; hyap isoforms ... See more keywords
Identification and Functional Analysis of Chitin Synthase A in Oriental Armyworm, Mythimna separata
Sign Up to like & getrecommendations! Published in 2017 at "PROTEOMICS"
DOI: 10.1002/pmic.201700165
Abstract: Chitin synthases are very important enzymes for chitin synthesis in various species, which makes them a specific target of insecticides. In the present study, the function of the chitin synthase A (CHSA) gene isolated from… read more here.
Keywords: chitin synthase; analysis chitin; chitin; identification functional ... See more keywords
An identification and functional evaluation of a novel CYP2C9 variant CYP2C9*62.
Sign Up to like & getrecommendations! Published in 2020 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2020.109168
Abstract: Warfarin is the most commonly used anticoagulant in the clinical treatment of thromboembolic diseases. The dose of warfarin varies significantly within populations, and the dose is closely related to the genetic polymorphisms of the CYP2C9… read more here.
Keywords: functional evaluation; evaluation novel; identification functional; cyp2c9 ... See more keywords
Identification of a functional FADS1 3'UTR variant associated with erythrocyte n-6 polyunsaturated fatty acids levels.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of clinical lipidology"
DOI: 10.1016/j.jacl.2018.07.012
Abstract: BACKGROUND Blood polyunsaturated fatty acid (PUFA) levels are determined by diet and by endogenous synthesis via Δ5- and Δ6-desaturases (encoded by the FADS1 and FADS2 genes, respectively). Genome-wide association studies have reported associations between FADS1-FADS2… read more here.
Keywords: polyunsaturated fatty; fads1 fads2; variant; fads1 utr ... See more keywords
Identification and functional analysis of ferritin 2 from the Taiga tick Ixodes persulcatus Schulze.
Sign Up to like & getrecommendations! Published in 2020 at "Ticks and tick-borne diseases"
DOI: 10.1016/j.ttbdis.2020.101547
Abstract: Ferritin 2 (FER2) is an iron storage protein, which has been shown to be critical for iron homeostasis during blood feeding and reproduction in ticks and is therefore suitable as a component for anti-tick vaccines.… read more here.
Keywords: fer2; tick; ixodes persulcatus; analysis ... See more keywords
Identification and Functional Characterization of Fungal Chalcone Synthase and Chalcone Isomerase
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Natural Products"
DOI: 10.1021/acs.jnatprod.2c01027
Abstract: By mining fungal genomic information, a noncanonical iterative type I PKS fused with an N-terminal adenylation–thiolation didomain, which catalyzes the formation of naringenin chalcone, was found. Structural prediction and molecular docking analysis indicated that a… read more here.
Keywords: chalcone synthase; functional characterization; identification functional; fungal chalcone ... See more keywords
Identification and functional validation of super-enhancers in Arabidopsis thaliana
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2215328119
Abstract: Significance Super-enhancers (SEs) are exceptionally large enhancers and play prominent roles in cell type identity and function in mammalian species. We identified a set of 749 putative SEs in the model plant Arabidopsis thaliana. We… read more here.
Keywords: identification functional; super enhancers; validation super; functional validation ... See more keywords
Identification and functional analysis of two new de novo KCNMA1 variants associated with Liang–Wang syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Acta Physiologica"
DOI: 10.1111/apha.13800
Abstract: Loss‐of‐function KCNMA1 variants cause Liang–Wang syndrome (MIM #618729), a newly identified multiple malformation syndrome with a broad spectrum of developmental and neurological phenotypes. However, the full spectrum of clinical features and underlying pathogenic mechanisms need… read more here.
Keywords: identification functional; analysis two; liang wang; wang syndrome ... See more keywords
Identification and functional expression of a new xylose isomerase from the goat rumen microbiome in Saccharomyces cerevisiae.
Sign Up to like & getrecommendations! Published in 2022 at "Letters in applied microbiology"
DOI: 10.1111/lam.13689
Abstract: The current climate crisis demands replacement of fossil energy sources with sustainable alternatives. In this scenario, second-generation bioethanol, a product of lignocellulosic biomass fermentation, represents a more sustainable alternative. However, Saccharomyces cerevisiae cannot metabolize pentoses,… read more here.
Keywords: xylose isomerase; identification functional; isomerase; goat rumen ... See more keywords
PO-033 Identification and functional evaluation of monoclonal antibodies specifically targeting human carbonic anhydrase IX
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.568
Abstract: Introduction Poor vascularisation of solid tumours leads to inadequate nutrient and oxygen supplies which forces tumour cells to reprogram their metabolism. As a consequence the tumour cell’s environment becomes acidic and hypoxic. This, in turn,… read more here.
Keywords: functional evaluation; carbonic anhydrase; 033 identification; monoclonal antibodies ... See more keywords
Identification and Functional Characterization of a Novel Variant in the SEMA3A Gene in a Chinese Family with Kallmann Syndrome
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Endocrinology"
DOI: 10.1155/2022/2504660
Abstract: Background Kallmann syndrome (KS) is a rare genetic disease characterized by the reproductive system and olfactory dysplasia due to the defective migration of gonadotropin-releasing hormone (GnRH) neurons. However, this disorder is clinically heterogeneous and the… read more here.
Keywords: functional characterization; novel variant; family; identification functional ... See more keywords