Identification of Gut Bacterial Enzymes for Keto-Reductive Metabolism of Xenobiotics.
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DOI: 10.1021/acschembio.2c00312
Abstract: Human gastrointestinal microbiota are known for the keto-reductive metabolism of small-molecule pharmaceuticals; however, the responsible enzymes remain poorly understood. Through in vitro biochemical assays, we report the identification of enzymes encoded in the genome of… read more here.
Keywords: reductive metabolism; gut bacterial; identification gut; keto reductive ... See more keywords
Identification of gut microbiome and transcriptome changes in ulcerative colitis and pouchitis
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DOI: 10.1080/00365521.2022.2047221
Abstract: Abstract Background Pouchitis is the common postoperative complication of ulcerative colitis (UC) and is also considered as inflammatory bowel disease. The aim was to investigate the microbiological and transcriptional differences between the two illnesses. Methods… read more here.
Keywords: microbiome transcriptome; ulcerative colitis; pouchitis; identification gut ... See more keywords