Identification of the Initial Steps in Signal Transduction in the α4β2 Nicotinic Receptor: Insights from Equilibrium and Nonequilibrium Simulations.
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DOI: 10.1016/j.str.2019.04.008
Abstract: Nicotinic acetylcholine receptors (nAChRs) modulate synaptic transmission in the nervous system. These receptors have emerged as therapeutic targets in drug discovery for treating several conditions, including Alzheimer's disease, pain, and nicotine addiction. In this in… read more here.
Keywords: equilibrium nonequilibrium; initial steps; identification initial; steps signal ... See more keywords