Identification of Lasso Peptide Topologies Using Native Nanoelectrospray Ionization-Trapped Ion Mobility Spectrometry-Mass Spectrometry.
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DOI: 10.1021/acs.analchem.7b05230
Abstract: Lasso peptides are a fascinating class of bioactive ribosomal natural products characterized by a mechanically interlocked topology. In contrast to their branched-cyclic forms, lasso peptides have higher stability and have become a scaffold for drug… read more here.
Keywords: identification lasso; native nanoelectrospray; spectrometry; mobility ... See more keywords