New insights into the composition of historical remedies and pharmaceutical formulations: the identification of natural resins and balsams by gas chromatographic-mass spectrometric investigations
Sign Up to like & getrecommendations! Published in 2020 at "Archaeological and Anthropological Sciences"
DOI: 10.1007/s12520-020-01236-6
Abstract: The present paper reports one of the first studies on the identification of natural resins and balsams in modern era drug formulations. Gas chromatography coupled with mass spectrometry (GC-MS) was applied to investigate the composition… read more here.
Keywords: resin; remedies pharmaceutical; natural resins; identification natural ... See more keywords
bioNMR-based identification of natural anti-Aβ compounds in Peucedanum ostruthium.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.10.016
Abstract: The growing interest in medicinal plants for the identification of new bioactive compounds and the formulation of new nutraceuticals and drugs prompted us to develop a powerful experimental approach allowing the detailed metabolic profiling of… read more here.
Keywords: peucedanum ostruthium; bionmr based; identification natural; identification ... See more keywords
An automatic approach for identification of natural reciprocal screw systems of serial kinematic chains based on the invariance properties matrix
Sign Up to like & getrecommendations! Published in 2017 at "Mechanism and Machine Theory"
DOI: 10.1016/j.mechmachtheory.2016.08.002
Abstract: Abstract This paper describes an automatic procedure for identifying a set of (6 − f ) natural constraint wrenches, termed natural reciprocal screws, for f read more here.
Keywords: approach identification; natural reciprocal; identification natural; reciprocal screw ... See more keywords
Identification of Natural Products Inhibiting SARS-CoV-2 by Targeting Viral Proteases: A Combined in Silico and in Vitro Approach
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Natural Products"
DOI: 10.1021/acs.jnatprod.2c00843
Abstract: In this study, an integrated in silico–in vitro approach was employed to discover natural products (NPs) active against SARS-CoV-2. The two SARS-CoV-2 viral proteases, i.e., main protease (Mpro) and papain-like protease (PLpro), were selected as… read more here.
Keywords: identification natural; viral proteases; natural products; vitro approach ... See more keywords
Identification of natural cytochalasins as leads for neglected tropical diseases drug discovery
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0275002
Abstract: Investigating the chemical diversity of natural products from tropical environments is an inspiring approach to developing new drug candidates for neglected tropical diseases (NTDs). In the present study, phenotypic screenings for antiprotozoal activity and a… read more here.
Keywords: identification natural; tropical diseases; natural cytochalasins; neglected tropical ... See more keywords
Identification Of Natural Compound Derivative For Inhibition Of XLF And Overcoming Chemoresistance In Colorectal Cancer Cells
Sign Up to like & getrecommendations! Published in 2019 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s215967
Abstract: Purpose A previous study has identified that XRCC4-like factor (XLF) is a potential target to overcome resistance to 5-fluorouracil (5-Fu) and oxaliplatin (OXA) in colorectal cancer (CRC). The purpose of this study is to develop… read more here.
Keywords: chemoresistance; crc; xlf; colorectal cancer ... See more keywords
Computer-Aided Drug Discovery Approaches in the Identification of Natural Products against SARS-CoV-2: A Review.
Sign Up to like & getrecommendations! Published in 2023 at "Current computer-aided drug design"
DOI: 10.2174/1573409919666230329090403
Abstract: BACKGROUND The COVID-19 pandemic is raising a worldwide search for compounds that could act against the disease, mainly due to its mortality. With this objective, many researchers invested in the discovery and development of drugs… read more here.
Keywords: identification natural; review; natural products; products sars ... See more keywords
Identification of Natural Products as SENP2 Inhibitors for Targeted Therapy in Heart Failure
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.817990
Abstract: Aims: Sentrin-specific protease -2 (SENP2) is involved in deSUMOylation. Increased deSUMOylation in murine hearts by SENP2 upregulation resulted in cardiac dysfunction and congenital heart defects. Natural compounds via regulating cell proliferation and survival, induce cell… read more here.
Keywords: identification natural; heart failure; senp2; natural products ... See more keywords