Nontargeted Identification of Reactive Metabolite Protein Adducts.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.6b04604
Abstract: Metabolic bioactivation of many different chemicals results in the formation of highly reactive compounds (chemically reactive metabolites, CRMs) that can lead to toxicity via binding to macromolecular targets (e.g., proteins or DNA). There is a… read more here.
Keywords: protein; reactive metabolite; nontargeted identification; identification reactive ... See more keywords
Identification of reactive intermediate formation and bioactivation pathways in Abemaciclib metabolism by LC–MS/MS: in vitro metabolic investigation
Sign Up to like & getrecommendations! Published in 2019 at "Royal Society Open Science"
DOI: 10.1098/rsos.181714
Abstract: Abemaciclib (Verzenio®) is approved as a tyrosine kinase inhibitor (TKI) for breast cancer treatment. In this study, in vitro phase I metabolic profiling of Abemaciclib (ABC) was done using rat liver microsomes (RLMs). We checked… read more here.
Keywords: vitro metabolic; metabolism; identification reactive; formation ... See more keywords