A procedure combining molecular docking and semiempirical method PM7 for identification of selective Shp2 inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Biopolymers"
DOI: 10.1002/bip.23320
Abstract: Shp2 and Shp1 make up a small family of protein tyrosine phosphatases. Finding selective inhibitors for Shp2 is useful because although its inhibition is advantageous for the treatment of some types of cancer, inhibition of… read more here.
Keywords: shp2; identification selective; shp2 shp1; interaction ... See more keywords
Identification of Selective, Cell Active Inhibitors of Protein Arginine Methyltransferase 5 through Structure-Based Virtual Screening and Biological Assays
Sign Up to like & getrecommendations! Published in 2018 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.8b00050
Abstract: Protein arginine methyltransferase 5 (PRMT5), a type II PRMT enzyme, is reported as an important therapeutic target in leukemia and lymphoma. In the present study, based on the combination of virtual screening and biochemical validations,… read more here.
Keywords: virtual screening; arginine methyltransferase; protein arginine; identification selective ... See more keywords
Identification of Selective Imidazopyridine CSF1R Inhibitors.
Sign Up to like & getrecommendations! Published in 2024 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.4c00110
Abstract: Colony stimulating factor-1 receptor (CSF1R or c-FMS), a class III receptor tyrosine kinase expressed on members of the mononuclear phagocyte system (MPS), plays a key role in the proper functioning of macrophages, microglia, and related… read more here.
Keywords: csf1r; chemistry; csf1r inhibitors; identification selective ... See more keywords
Abstract 6379: Identification of selective, orally bioavailable aurora A degraders for treatment of pediatric and adult cancers
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-6379
Abstract: Aurora A kinase (AURKA) is an oncogene frequently overexpressed in adult solid tumors, hematologic malignancies, and pediatric cancers. AURKA plays an important role in mitosis, and cancer cells sensitive to loss of AURKA include lines… read more here.
Keywords: aurka; cancer; aurka degraders; identification selective ... See more keywords
Identification of Selective CYP3A7 and CYP3A4 Substrates and Inhibitors Using a High-Throughput Screening Platform
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.899536
Abstract: Cytochrome P450 (CYP) 3A7 is one of the major xenobiotic metabolizing enzymes in human embryonic, fetal, and newborn liver. CYP3A7 expression has also been observed in a subset of the adult population, including pregnant women,… read more here.
Keywords: cyp3a7; identification selective; p450 glo; metabolic stability ... See more keywords