Computational Identification of Small Interfering RNA Targets in SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2020 at "Virologica Sinica"
DOI: 10.1007/s12250-020-00221-6
Abstract: With the epidemic of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) worldwide and in the absence of any effective vaccine, there is an urgent need to find a specific anti- SARS-CoV-2 agent. In this study,… read more here.
Keywords: small interfering; identification small; interfering rna; rna targets ... See more keywords
Identification of small molecule compounds active against Staphylococcus aureus and Proteus mirabilis.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.10.189
Abstract: Staphylococcus aureus is a human pathogen rapidly becoming a serious health problem due to ease of acquiring antibiotic resistance. To help identify potential new drug candidates effective against the pathogen, a small focused library was… read more here.
Keywords: staphylococcus aureus; small molecule; aureus; mirabilis ... See more keywords
Identification of small-molecule ligands that bind to MiR-21 as potential therapeutics for endometriosis by screening ZINC database and in-vitro assays.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.03.094
Abstract: MicroRNA-21 (miR-21) is an important regulator of cell signaling pathways involved in the pathogenesis of endometriosis. Here, we attempted to discover new ligands of miR-21 pre-element by carrying out stepwise high-throughput virtual screening against a… read more here.
Keywords: identification small; element; small molecule; pre element ... See more keywords
Enrichment and identification of small proteins in a simplified human gut microbiome.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2019.103604
Abstract: Small proteins (sProteins) with a size of 100 amino acids and less are involved in major biological processes and play an important role in different bacteria. Despite the increasing interest in them, the data on… read more here.
Keywords: human gut; small proteins; gut microbiome; microbiome ... See more keywords
Identification of small molecules disrupting the ubiquitin proteasome system in malaria.
Sign Up to like & getrecommendations! Published in 2019 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.9b00216
Abstract: The Ubiquitin Proteasome System (UPS) is one of the main proteolytic pathways in eukaryotic cells, playing an essential role in key cellular processes such as cell cycling and signal transduction. Changes in some of the… read more here.
Keywords: falciparum ups; proteasome system; identification small; ubiquitin proteasome ... See more keywords
Identification of Small Molecule Inhibitors of a Mir155 Transcriptional Reporter in Th17 Cells
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-90944-7
Abstract: MicroRNA miR-155 is an important regulatory molecule in the immune system and is highly expressed and functional in Th17 cells, a subset of CD4+ T helper cells which are key players in autoimmune diseases. Small… read more here.
Keywords: molecule; th17 cells; mir155 reporter; identification small ... See more keywords
Identification of small molecules against cyclin dependent kinase-5 using chemoinformatics approach for Alzheimer’s disease and other tauopathies
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1844050
Abstract: Abstract Alzheimer’s disease (AD) is a multifactorial complex and wide spreading global disease. It is a chronic neurodegenerative disorder characterized by amyloid beta (Aβ) and neurofibrillary tangles (NFTs). Several enzymes are involved in which CDK5… read more here.
Keywords: molecules cyclin; small molecules; disease; identification small ... See more keywords
Identification of Small Molecules with Improved Potency against Orthopoxviruses from Vaccinia to Smallpox
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00841-22
Abstract: The genus Orthopoxvirus contains several human pathogens, including vaccinia, monkeypox, cowpox, and variola virus, the causative agent of smallpox. Although there are a few effective vaccines, widespread prophylactic vaccination has ceased and is unlikely to… read more here.
Keywords: molecules improved; potency; variola virus; identification small ... See more keywords
Identification of small inhibitors for human Metadherin, an oncoprotein, through Insilco approach.
Sign Up to like & getrecommendations! Published in 2023 at "Current computer-aided drug design"
DOI: 10.2174/1573409919666230110112356
Abstract: AIMS Cancer is a disease that takes lives of thousands of people each year. There are more than 100 different types of cancers known to man. This fatal disease is one of the leading causes… read more here.
Keywords: small inhibitors; identification small; snd1; approach ... See more keywords
Identification of Small-Molecule Inhibitors of Brucella Diaminopimelate Decarboxylase by Using a High-Throughput Screening Assay
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2019.02936
Abstract: Brucellosis, caused by intracellular gram-negative pathogens of the genus Brucella, continues to be one of the most pandemic zoonotic diseases in most countries. At present, the therapeutic treatment of brucellosis relies on a combination of… read more here.
Keywords: brucella; diaminopimelate decarboxylase; high throughput; identification small ... See more keywords
Identification of Small RNAs Associated with Salt Stress in Chrysanthemums through High-Throughput Sequencing and Bioinformatics Analysis
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14030561
Abstract: The Chrysanthemum variety “Niu 9717” exhibits excellent characteristics as an ornamental plant and has good salt resistance. In this study, this plant was treated with 200 mM NaCl for 12 h followed by high-throughput sequencing… read more here.
Keywords: identification small; high throughput; throughput sequencing; salt stress ... See more keywords