Identification, Synthesis, and Characterization of Novel Baricitinib Impurities
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DOI: 10.1021/acsomega.3c00100
Abstract: Baricitinib is a novel active pharmaceutical ingredient used in the treatment of rheumatoid arthritis, and it acts as an inhibitor of Janus kinase. During the synthesis of baricitinib, three unknown impurities were identified in several… read more here.
Keywords: characterization novel; baricitinib; synthesis characterization; synthesis ... See more keywords
Identification, synthesis and biological activity of alkyl-guanidine oligomers as potent antibacterial agents
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DOI: 10.1038/s41598-017-08749-6
Abstract: In the last two decades, the repertoire of clinically effective antibacterials is shrinking due to the rapidly increasing of multi-drug-resistant pathogenic bacteria. New chemical classes with innovative mode of action are required to prevent a… read more here.
Keywords: biological activity; alkyl guanidine; activity alkyl; synthesis biological ... See more keywords
Identification, synthesis and characterization of avanafil process impurities and determination by UPLC
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DOI: 10.1039/d2ra01224c
Abstract: Avanafil is a phosphodiesterase type 5 inhibitor which is used to treat erectile dysfunction in men. The process-related impurities of avanafil were investigated, and four kinds of impurities in several laboratory batches with a content… read more here.
Keywords: identification synthesis; synthesis; characterization; process ... See more keywords
Computer-aided identification, synthesis, and biological evaluation of DNA polymerase η inhibitors for the treatment of cancer.
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DOI: 10.2139/ssrn.4200126
Abstract: In cancer cells, Pol η allows DNA replication and cell proliferation even in the presence of chemotherapeutic drug-induced damages, like in the case of platinum-containing drugs. Inhibition of Pol η thus represents a promising strategy… read more here.
Keywords: synthesis biological; aided identification; identification synthesis; computer aided ... See more keywords
Identification, synthesis and spectral characterization of a potential impurity of ceftazidime
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Food and Drug Analysis"
DOI: 10.38212/2224-6614.2278
Abstract: During the process development of ceftazidime, a new impurity which exceeded the limit of 0.1% was detected by a simple HPLC method. The molecular weight of the target impurity was determined by LC/MS. This suspected… read more here.
Keywords: impurity ceftazidime; synthesis spectral; impurity; ceftazidime ... See more keywords