Comprehensive metabolomics study identifies SN-38 organ specific toxicity in mice
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DOI: 10.1038/s41598-025-01753-1
Abstract: SN-38 (7-ethyl-10-hydroxycamptothecin), the active metabolite of irinotecan, is a crucial anticancer agent frequently studied in drug delivery systems. Irinotecan (CPT-11) is used to treat various solid tumors but is associated with adverse effects such as… read more here.
Keywords: mice; study identifies; toxicity; identifies organ ... See more keywords