theLiTE™: A Screening Platform to Identify Compounds that Reinforce Tight Junctions
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DOI: 10.3389/fphar.2021.752787
Abstract: Tight junctions (TJ) are formed by transmembrane and intracellular proteins that seal the intercellular space and control selective permeability of epithelia. Integrity of the epithelial barrier is central to tissue homeostasis and barrier dysfunction has… read more here.
Keywords: par; identify compounds; tight junctions; screening platform ... See more keywords
Broadly Applicable, Virus-Free Dual Reporter Assay to Identify Compounds Interfering with Membrane Fusion: Performance for HSV-1 and SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14071354
Abstract: Membrane fusion constitutes an essential step in the replication cycle of numerous viral pathogens, hence it represents an important druggable target. In the present study, we established a virus-free, stable reporter fusion inhibition assay (SRFIA)… read more here.
Keywords: cell; fusion; membrane fusion; identify compounds ... See more keywords