Urine mRNA to identify a novel pseudoexon causing dystrophinopathy
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.777
Abstract: In muscular dystrophies, identification of pathogenic pseudoexons involves sequencing of the target gene cDNA derived from muscle mRNA. Here we use a urine “liquid biopsy,” droplet digital PCR, and sequencing of PCR products to identify… read more here.
Keywords: identify novel; pseudoexon causing; novel pseudoexon; urine mrna ... See more keywords
A Transcriptomic Approach to Identify Novel Drug Efflux Pumps in Bacteria.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7454-2_12
Abstract: The core genomes of most bacterial species include a large number of genes encoding putative efflux pumps. The functional roles of most of these pumps are unknown, however, they are often under tight regulatory control… read more here.
Keywords: novel drug; identify novel; drug efflux; efflux pumps ... See more keywords
Using Affinity Purification Coupled with Stable Isotope Labeling by Amino Acids in Cell Culture Quantitative Mass Spectrometry to Identify Novel Interactors/Substrates of Protein Arginine Methyltransferases.
Sign Up to like & getrecommendations! Published in 2019 at "Methods"
DOI: 10.1016/j.ymeth.2019.11.015
Abstract: The protein arginine methyltransferase family (PRMT) is known as being the catalytic driving force for arginine methylation. This specific type of post translational modification is extensively used in biological processes, and therefore is highly relevant… read more here.
Keywords: interactors substrates; identify novel; purification coupled; protein arginine ... See more keywords
Abstract 1360: A PARylation biosensor genetic screen to identify novel PARylation targets
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-1360
Abstract: Poly(ADP-ribosylation) (PARylation) is a reversible post-translational protein modification that regulates a number of cellular processes. It is generated by a family of PAR polymerases (PARP), of which PARP1 has recently been exploited as a target… read more here.
Keywords: novel parylation; identify novel; biosensor; parylation targets ... See more keywords
Advances in omics-based methods to identify novel targets for malaria and other parasitic protozoan infections
Sign Up to like & getrecommendations! Published in 2019 at "Genome Medicine"
DOI: 10.1186/s13073-019-0673-3
Abstract: A major advance in antimalarial drug discovery has been the shift towards cell-based phenotypic screening, with notable progress in the screening of compounds against the asexual blood stage, liver stage, and gametocytes. A primary method… read more here.
Keywords: omics based; identify novel; drug; methods identify ... See more keywords
A network-based method using a random walk with restart algorithm and screening tests to identify novel genes associated with Menière's disease
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0182592
Abstract: As a chronic illness derived from hair cells of the inner ear, Menière’s disease (MD) negatively influences the quality of life of individuals and leads to a number of symptoms, such as dizziness, temporary hearing… read more here.
Keywords: network based; network; identify novel; novel genes ... See more keywords
Reverse vaccinology approach to identify novel and immunogenic targets against Porphyromonas gingivalis: An in silico study
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0273770
Abstract: Porphyromonas gingivalis is a primary causative agent of chronic periodontitis. Moreover, it leads to several systemic diseases, including rheumatoid arthritis, cardiovascular, neurodegenerative, and Alzheimer’s diseases. It seems that the development of a vaccine against this… read more here.
Keywords: reverse vaccinology; immunogenic targets; identify novel; novel immunogenic ... See more keywords
Mechanisms of resistance to a PI3K inhibitor in gastrointestinal stromal tumors: an omic approach to identify novel druggable targets
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Management and Research"
DOI: 10.2147/cmar.s189661
Abstract: Background: Gastrointestinal stromal tumors (GISTs) represent a worldwide paradigm of target therapy. The introduction of tyrosine kinase inhibitors has deeply changed the prognosis of GIST patients, however, the majority of them acquire secondary mutations and… read more here.
Keywords: stromal tumors; druggable targets; identify novel; pi3k inhibitor ... See more keywords
Integrated Analysis of Microarray Studies to Identify Novel Diagnostic Markers in Bladder Pain Syndrome/Interstitial Cystitis with Hunner Lesion
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of General Medicine"
DOI: 10.2147/ijgm.s351287
Abstract: Background The aim of this study was to identify novel genetic features of Hunner’s lesion interstitial cystitis (HIC) via comprehensive analysis of the Gene Expression Omnibus (GEO) database. Methods The GSE11783 and GSE28242 datasets were… read more here.
Keywords: identify novel; interstitial cystitis; analysis; hunner lesion ... See more keywords
New Pathways Identify Novel Drug Targets for the Prevention and Treatment of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065383
Abstract: Alzheimer’s disease (AD) is an incurable, progressive neurodegenerative disorder. AD is a complex and multifactorial disease that is responsible for 60–80% of dementia cases. Aging, genetic factors, and epigenetic changes are the main risk factors… read more here.
Keywords: pathways identify; disease; alzheimer disease; identify novel ... See more keywords
An In Silico Target Fishing Approach to Identify Novel Ochratoxin A Hydrolyzing Enzyme
Sign Up to like & getrecommendations! Published in 2020 at "Toxins"
DOI: 10.3390/toxins12040258
Abstract: Ochratoxin A (OTA), a mycotoxin that is of utmost concern in food and feed safety, is produced by fungal species that mainly belong to the Aspergillus and Penicillium genera. The development of mitigation strategies to… read more here.
Keywords: identify novel; ota hydrolyzing; novel ota; hydrolyzing enzyme ... See more keywords